| Autor: |
Bijsterveld NR; Department of Cardiology, Room F3-241, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ , PO Box 22660, 1100 DD Amsterdam, The Netherlands. n.r.bijsterveld@amc.uva.nl, Vink R, van Aken BE, Fennema H, Peters RJ, Meijers JC, Büller HR, Levi M |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of haematology [Br J Haematol] 2004 Mar; Vol. 124 (5), pp. 653-8. |
| DOI: |
10.1111/j.1365-2141.2003.04811.x |
| Abstrakt: |
We investigated whether the anticoagulant effect of idraparinux, a selective long-acting factor Xa inhibitor, could be neutralized by recombinant factor VIIa (rFVIIa) in healthy male volunteers. We performed a randomized, placebo-controlled trial, comparing idraparinux [7.5 mg subcutaneous (s.c.)] followed at 3 h by rFVIIa [90 microg/kg intravenous (i.v.)] (n = 6), or idraparinux (7.5 mg s.c) followed after 1 week by rFVIIa (90 microg/kg i.v.)(n = 6). rFVIIa, given 3 h after idraparinux, significantly reversed the increased thrombin generation time (TGT), the increased activated partial thromboplastin time (aPTT) and prothrombin time (PT), and the reduced prothrombin fragment 1+2 (F1+2) levels caused by idraparinux, although no clear effect of rFVIIa on the endogenous thrombin potential (ETP) was observed. One week after idraparinux, injection of rFVIIa resulted in a similar relative reduction of the remaining increased aPTT, PT and TGT, with correction to pre-idraparinux values. A clear increase of F1+2 was observed, together with a small increase in ETP. We conclude that rFVIIa has significant effects on the idraparinux-inhibited thrombin generation and clotting parameters. These results suggest that rFVIIa may be useful in serious bleeding complications in idraparinux treated patients. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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