[Preclinical evaluation of the therapeutic efficacy of L-dopa in chronic gastric ulcer].

Autor: Baranovskiĭ AIu, Smolianinov AB, Zavodskaia IS, Nilova TN
Jazyk: ruština
Zdroj: Patologicheskaia fiziologiia i eksperimental'naia terapiia [Patol Fiziol Eksp Ter] 1992 May-Jun (3), pp. 35-7.
Abstrakt: The authors studied the peculiarities of the course taken by experimental gastric ulcer in rabbits under the effect of the norepinephrine precursor 1-dioxyphenylalanine (L-DOPA) injected parenterally in a dose of 10 mg/kg twice a day for 14 days. As compared to the controls (nontreated ulcer), L-DOPA restored significantly more rapidly the bioenergetic processes in the gastric mucosa which were disturbed as the result of ulcerogenesis, provided for stimulation of reparative regeneration, and reduced the terms of ulcer cicatrization.
Databáze: MEDLINE