| Autor: |
Marx CW; Division of Diabetes and Endocrinology, Scripps Clinic and Research Foundation, La Jolla, California., Dailey GE 3rd, Cheney C, Vint VC 2nd, Muchmore DB |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research [J Bone Miner Res] 1992 Nov; Vol. 7 (11), pp. 1275-9. |
| DOI: |
10.1002/jbmr.5650071122 |
| Abstrakt: |
A retrospective analysis of our experience with estrogen and fluoride treatment in 91 patients with postmenopausal osteopenia followed for 6-47 months has been performed. Treatment included calcium (1000 mg/day) and either conjugated estrogens (0.625 mg/day) or sodium fluoride (50 mg/day), or both. All patients had at least two serial dual-photon spinal bone mineral density measurements performed 6 months or more apart. Estrogen treatment was associated with increased bone mineral density (5.3%/year), as was fluoride alone (7.5%/year). Estrogen and fluoride together were additive (9.6%/year). In women over age 65 the estrogen effect was just as great (6.9%/year) as in younger women. Estrogen benefit occurred predominantly in the first 18 months of treatment (7.0%/year), after which time changes in bone mineral density were similar to those in untreated controls, who showed stable bone mineral density. We conclude that aggressive estrogen and fluoride treatment tailored to the severity of the individual's postmenopausal osteopenia results in short-term improvement in spinal bone mineral density. These data further support that elderly women respond to estrogen replacement therapy with absolute and relative increments in bone density similar to those in younger women. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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