Nuclear chromatin texture in rectal carcinoma. Prognostic value.
| Autor: | Rosito MA; Department of Coloproctological Surgery, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Damin DC, Moreira LF, da Silva VD, Prolla JC |
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| Jazyk: | angličtina |
| Zdroj: | Analytical and quantitative cytology and histology [Anal Quant Cytol Histol] 2003 Aug; Vol. 25 (4), pp. 215-20. |
| Abstrakt: | Objective: To investigate the prognostic value of nuclear features in rectal carcinoma. Study Design: High-resolution imagery of 3,635 nuclei from 51 patients operated on for rectal cancer at various Dukes' stages was digitally recorded. A set of 93 features descriptive of the spatial and statistical distribution of nuclear chromatin was computed for each nucleus to derive a digital signature. Karyometric features were analyzed for correlation with progression of disease and death. Results: Multivariate analysis of main karyometric features in comparison with cancer staging demonstrated that total optical density and clumpness, as well as average nuclear signature, had significant prognostic value in predicting cancer-related death. Conclusion: Digital signature seems to have a role as prognostic factor in rectal cancer. The method could be a useful parameter in deciding whether to perform adjuvant therapy in particular subgroups of patients, independently of tumor staging. However, these observations need to be substantiated with additional studies, including larger numbers of patients. |
| Databáze: | MEDLINE |
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