| Autor: |
Hol EM; Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands. e.hol@nih.knaw.nl, Roelofs RF, Moraal E, Sonnemans MA, Sluijs JA, Proper EA, de Graan PN, Fischer DF, van Leeuwen FW |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular psychiatry [Mol Psychiatry] 2003 Sep; Vol. 8 (9), pp. 786-96. |
| DOI: |
10.1038/sj.mp.4001379 |
| Abstrakt: |
Glial fibrillary acidic protein (GFAP) is considered to be a highly specific marker for glia. Here, we report on the expression of GFAP in neurons in the human hippocampus. Intriguingly, this neuronal GFAP is coded by out-of-frame splice variants and its expression is associated with Alzheimer pathology. We identified three novel GFAP splice forms: Delta 135 nt, Delta exon 6 and Delta 164 nt. Neuronal GFAP is mainly observed in the pyramidal neurons of the hippocampus of Alzheimer and Down syndrome patients and aged controls, but not in neurons of patients suffering from hippocampal sclerosis. Apparently, the hippocampal neurons in patients with Alzheimer's disease pathology are capable of expressing glia-specific genes. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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