Analysis of plasma homocysteine levels in patients with unstable angina.

Autor:	Tavares JR; Universidade Federal de Sao Paulo, Brazil. jrtavares@directnet.com.br, D'Almeida V, Diniz DC, Terzi CA, Cruz EN, Stefanini E, Andriollo A, Paola AA, Carvalho AC
Jazyk:	English; Portuguese
Zdroj:	Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2002 Aug; Vol. 79 (2), pp. 161-72. Date of Electronic Publication: 2002 Sep 10.
DOI:	10.1590/s0066-782x2002001100008
Abstrakt:	Objective: To determine the prevalence of hyperhomocystinemia in patients with acute ischemic syndrome of the unstable angina type. Methods: We prospectively studied 46 patients (24 females) with unstable angina and 46 control patients (19 males), paired by sex and age, blinded to the laboratory data. Details of diets, smoking habits, medication used, body mass index, and the presence of hypertension and diabetes were recorded, as were plasma lipid and glucose levels, C-reactive protein, and lipoperoxidation in all participants. Patients with renal disease were excluded. Plasma homocysteine was estimated using high-pressure liquid chromatography. Results: Plasma homocysteine levels were significantly higher in the group of patients with unstable angina (12.7+/-6.7 micromol/L) than in the control group (8.7+/-4.4 micromol/L) (p<0.05). Among males, homocystinemia was higher in the group with unstable angina than in the control group, but this difference was not statistically significant (14.1+/-5.9 micromol/L versus 11.9+/-4.2 micromol/L). Among females, however, a statistically significant difference was observed between the 2 groups: 11.0+/-7.4 micromol/L versus 6.4+/-2.9 micromol/L (p<0.05) in the unstable angina and control groups, respectively. Approximately 24% of the patients had unstable angina at homocysteine levels above 15 micromol/L. Conclusion: High homocysteine levels seem to be a relevant prevalent factor in the population with unstable angina, particularly among females.
Databáze:	MEDLINE
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