Chromosomal amplification of the Escherichia coli lipB region confers high-level resistance to selenolipoic acid.

Autor: Jordan SW; Departments of Microbiology. Biochemistry, University of Illinois, Urbana, Illinois 61801, USA., Cronan JE Jr
Jazyk: angličtina
Zdroj: Journal of bacteriology [J Bacteriol] 2002 Oct; Vol. 184 (19), pp. 5495-501.
DOI: 10.1128/JB.184.19.5495-5501.2002
Abstrakt: One of the mutants (slr7 mutant) of a wild-type Escherichia coli strain resistant to selenolipoic acid reported previously (K. E. Reed, T. W. Morris, and J. E. Cronan, Jr., Proc. Natl. Acad. Sci. USA 91:3720-3724, 1994) unexpectedly grew on minimal medium following transductional introduction of a lipA null mutation. We report that the slr7 strain carries a duplication of the lip chromosomal region that causes the phenotype of the mutant strain.
Databáze: MEDLINE