| Autor: |
Jiang ZH; Biomira Inc., 2011-94 Street, Edmonton, T6N 1H1, Alberta, Canada. rkoganty@biomira.com, Bach MV, Budzynski WA, Krantz MJ, Koganty RR, Longenecker BM |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Aug 19; Vol. 12 (16), pp. 2193-6. |
| DOI: |
10.1016/s0960-894x(02)00362-1 |
| Abstrakt: |
Structurally well-defined immune stimulatory molecules are important components of new generation molecular vaccines. In this paper, the design and synthesis of two lipid A analogues containing an unnatural tri-lipid acyl group are described. In a totally synthetic liposomal vaccine system, these re-designed lipid A analogues demonstrate potent immune stimulatory properties including antigen specific T-cell activation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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