Synthesis and profile of SCH351591, a novel PDE4 inhibitor.

Autor: Billah M; Schering-Plough Corporation, Galloping Hill Road, Kenilworth, NJ 07033-0530, USA., Cooper N, Cuss F, Davenport RJ, Dyke HJ, Egan R, Ganguly A, Gowers L, Hannah DR, Haughan AF, Kendall HJ, Lowe C, Minnicozzi M, Montana JG, Naylor R, Oxford J, Peake JC, Piwinski JJ, Runcie KA, Sabin V, Sharpe A, Shih NY, Warneck JB
Jazyk: angličtina
Zdroj: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Jun 17; Vol. 12 (12), pp. 1621-3.
DOI: 10.1016/s0960-894x(02)00225-1
Abstrakt: The syntheses and pharmacological profiles of some 2-trifluoromethyl-8-methoxyquinoline-5-carboxamides are described. SCH351591 is a potent selective inhibitor of phosphodiesterase type 4 (PDE4).
Databáze: MEDLINE