Cardiovascular effects of romifidine in the standing horse.

Autor: Freeman SL; Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hawkshead lane, N.Mymms, Hatfield, Herts, AL9 7TA, UK. sfreeman@rvc.ac.uk, Bowen IM, Bettschart-Wolfensberger R, Alibhai HI, England GC
Jazyk: angličtina
Zdroj: Research in veterinary science [Res Vet Sci] 2002 Apr; Vol. 72 (2), pp. 123-9.
DOI: 10.1053/rvsc.2001.0533
Abstrakt: The cardiovascular effects of romifidine, an alpha-2 adrenoreceptor agonist, were investigated in six horses using two doses (80 and 120 microg kg(-1)) in a cross-over study design. Cardiac index and mixed venous oxygenation were significantly decreased at 15 and 30 minutes after both doses of romifidine. Systemic vascular resistance was significantly increased with romifidine (120 microg kg(-1)). Arterial blood pressure increased initially and then gradually decreased; the doses of decrease was significant at 90 and 120 minutes with romifidine 80 and 120 microg kg(-1). There were minimal differences between the two doses of romifidine, and both should be used with care especially in horses with cardiovascular compromise, or when used in combination with other cardiovascular depressant drugs.
(Copyright 2002 Published by Elsevier Science Ltd.)
Databáze: MEDLINE
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