| Autor: |
Mikhaĭlova LM; N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow., Koniaeva ON, Chlenova EL, Merkulova IB, Ermakova NP, Gavrilova TN, Sergeev AA |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy onkologii [Vopr Onkol] 2001; Vol. 47 (6), pp. 695-700. |
| Abstrakt: |
Pre-clinical toxicologic studies were conducted of a new drug teraphtal-Lio (TPh) and a teraphtal-Lio + ascorbic acid (TPh + AA) catalytic system recommended for binary catalytic therapy of malignant tumors. Quantitative criteria for "acute" and "chronic" toxicity of TPh and TPh + AA were established, which describe their toxic effects in single or multiple application. The coefficient of specific sensitivity and cumulation index for TPh and TPh + AA were determined. The toxicodynamic characteristics of TPh and TPh + AA were investigated. The results were used to prognose pulmonary, cardio-vascular, hemato- and hepatotoxic as well as hemodynamic and ophthalmologic disorders and functional changes in the central nervous system involved in clinical use of TPh and TPh + AA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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