| Autor: |
Pinho e Melo TM; Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, 3004-535 Coimbra, Portugal. tmelo@ci.uc.pt, Lopes CS, Gonsalves AM, Beja AM, Paixão JA, Silva MR, da Veiga LA |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of organic chemistry [J Org Chem] 2002 Jan 11; Vol. 67 (1), pp. 66-71. |
| DOI: |
10.1021/jo010504v |
| Abstrakt: |
Nucleophilic substitution reactions of 2-halo-2H-azirines 1a, 1b, 1d, and 1e with potassium phthalimide and aniline allowed the preparation of new substituted 2H-azirines 2-5. The reactions of 2-bromo-2H-azirine 1a with methylamine led to the synthesis of alpha-diimines 7 and 8. 2-Halo-2H-azirines were also established as building blocks for the synthesis of a range of heterocyclic compounds, namely, quinoxalines 10a-10d, 3-oxazoline 14, and 2H-[1,4]oxazines 18 and 20. X-ray crystal structures of alpha-diimine 7, 3-oxazoline 14, and 2H-[1,4]oxazine 18 are reported. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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