| Autor: |
Li H; Respiratory and Enteric Viruses Branch, Measles Section MS. D11, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA. hb11@cdc.gov, Hickman CJ, Helfand RF, Keyserling H, Anderson LJ, Bellini WJ |
| Jazyk: |
angličtina |
| Zdroj: |
Vaccine [Vaccine] 2001 Sep 14; Vol. 19 (32), pp. 4896-900. |
| DOI: |
10.1016/s0264-410x(01)00227-4 |
| Abstrakt: |
To better characterize the cytokine response to measles virus vaccine, we examined the levels of IL-2, IL-4, IL-5, IL-10, IL-12 and gamma-interferon (gamma-IFN) in measles virus-stimulated peripheral blood mononuclear cells from 18 donors before and 2 weeks after vaccination. Donors were grouped as seropositive or seronegative on the basis of measles-specific IgM antibody present at 2 weeks postvaccination. After vaccination, similar levels of upregulation of IL-2 and gamma-IFN mRNA were observed in the two groups. The majority of donors in both groups did not exhibit an increase in measles specific IL-4 or IL-10 mRNA after vaccination. IL-12 mRNA was not induced by measles virus in any of the donors. A statistically significant upregulation of IL-5 mRNA was observed among seropositive (9/13) compared with seronegative (1/5) donors after vaccination (P=0.09, one tailed Fisher's test). The observed measles specific induction of IL-5 mRNA is suggestive of a possible association between IL-5 production and an antibody response to measles virus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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