Impact of prednisone on TGF-beta1 and collagen in diaphragm muscle from mdx mice.

Autor: Hartel JV; Department of Physical Therapy, Exercise and Nutrition Sciences, 405 Kimball Tower, State University of New York at Buffalo, Buffalo, New York 14214, USA., Granchelli JA, Hudecki MS, Pollina CM, Gosselin LE
Jazyk: angličtina
Zdroj: Muscle & nerve [Muscle Nerve] 2001 Mar; Vol. 24 (3), pp. 428-32.
DOI: 10.1002/1097-4598(200103)24:3<428::aid-mus1018>3.0.co;2-e
Abstrakt: The purpose of this study was to assess the impact of prednisone treatment for 8 weeks on the level of transforming growth factor-beta 1 (TGF-beta1), hydroxyproline (HYP) concentrations, and level of the mature, nonreducible collagen cross-link hydroxylysylpyridinoline (HP) in diaphragm muscle from 12-week-old mdx mice. Diaphragm muscle from untreated mdx mice had a significantly higher level of TGF-beta1, HYP, and HP cross-link compared with normal C57BL/10J (control) mice. Prednisone treatment significantly reduced the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but resulted in a higher level of the HP cross-link compared with untreated mdx mice. These findings indicate that short-term treatment of mdx mice with prednisone can attenuate the fibrotic response in diaphragm muscle, possibly by mediating the level of TGF-beta. Although prednisone was beneficial in preventing collagen accumulation, it resulted in a higher level of the HP cross-link, presumably by decreasing collagen turnover
(Copyright 2001 John Wiley & Sons, Inc.)
Databáze: MEDLINE
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