| Autor: |
Campbell SC; Department of Molecular and Cell Biology, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen, UK., Cragg H, Elrick LJ, Macfarlane WM, Shennan KI, Docherty K |
| Jazyk: |
angličtina |
| Zdroj: |
FEBS letters [FEBS Lett] 1999 Dec 10; Vol. 463 (1-2), pp. 53-7. |
| DOI: |
10.1016/s0014-5793(99)01584-7 |
| Abstrakt: |
Pax4 is a paired-box transcription factor that plays an important role in the development of pancreatic beta-cells. Two Pax4 cDNAs were isolated from a rat insulinoma library. One contained the full-length sequence of Pax4. The other, termed Pax4c, was identical to Pax4 but lacked the sequences encoding 117 amino acids at the COOH-terminus. Pax4 was found to inhibit the human insulin promoter through a sequence element, the C2 box, located at -253 to -244, and the islet amyloid polypeptide promoter through a sequence element located downstream of -138. The inhibitory activity of Pax4 was mapped to separate regions of the protein between amino acids 2-230 and 231-349. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text