| Autor: |
Griffin EA Jr; Department of Neurobiology, Harvard Medical School, Boston, MA 02115 USA., Staknis D, Weitz CJ |
| Jazyk: |
angličtina |
| Zdroj: |
Science (New York, N.Y.) [Science] 1999 Oct 22; Vol. 286 (5440), pp. 768-71. |
| DOI: |
10.1126/science.286.5440.768 |
| Abstrakt: |
Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila, binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a role for CRYs within the clock, distinct from hypothetical photoreceptor functions. Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator driving Per1 transcription. CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with PER1, PER2, and TIM. Thus, mammalian CRYs act as light-independent components of the circadian clock and probably regulate Per1 transcriptional cycling by contacting both the activator and its feedback inhibitors. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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