| Autor: |
Shultz MD; Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA., Chmielewski J |
| Jazyk: |
angličtina |
| Zdroj: |
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Aug 16; Vol. 9 (16), pp. 2431-6. |
| DOI: |
10.1016/s0960-894x(99)00400-x |
| Abstrakt: |
The importance of each side chain of a cross-linked interfacial peptide inhibitor of HIV-1 protease was evaluated using an alanine scanning approach. Whereas the parent inhibitor has an IC50 value of 350 nM, values for the mutations reported here range from 280-9200 nM. The relative importance or each residue was thus assigned and correlated to the solvent accessible surface area (SASA) exposed upon mutation. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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