| Autor: |
Kotsiuruba AV; A.V. Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv., Bukhanevich OM, Tarakanov SS, Tuhanova AV, Berdyshev AH, Mehed' OF |
| Jazyk: |
ukrajinština |
| Zdroj: |
Ukrainskii biokhimicheskii zhurnal (1978) [Ukr Biokhim Zh (1978)] 1998 Sep-Oct; Vol. 70 (5), pp. 30-7. |
| Abstrakt: |
We have examined in vivo capacities of two C27-steroid hormones-phytoecdysteroid ecdysterone (20-hydroxyecdysone, 10(-8)M) and calcitriol (1 alpha, 25-dihydroxyvitamin D3, 10(-12)M), as a modulators of neutral lipids hydrolysis in the brain and heart cells. Severe lines of evidence indicate that both hormones may acts as positive regulators of cholesterol esters and triacylglycerol hydrolysis in early (0.5-30 min) pregenomic phase of its actions, yielding known (DAG, free polyunsaturated fatty acids) and possible (free cholesterol) lipid second messengers. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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