| Autor: |
Igusheva OA; Institute of Cytology, Russian Academy of Sciences, St. Petersburg., Spivak IM, Mikhel'son VM, Pleskach NM, Zhestianikov VD |
| Jazyk: |
ruština |
| Zdroj: |
Tsitologiia [Tsitologiia] 1999; Vol. 41 (2), pp. 167-72. |
| Abstrakt: |
Transcriptionally activity-dependent heterogeneity of gamma-induced DNA single-strand break repair in ataxia-telangiectasia cells has been investigated. It is found that in AT cells no increased induction of damage in the c-myc gene compares with normal human fibroblasts. At the same time an evident defect of preferential accelerated repair of single-strand breaks in the c-myc gene was observed. DNA single-strand breaks repair in human satellite III and total DNA single-strand breaks in c-myc gene in AT cells correlate with increased radiosensitivity of cells. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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