| Autor: |
Zhang H; Department of Growth Factor Research, Pharmaceutical Products Division, Abbott Laboratories D-4MG, AP9A, Abbott Park, Ill. 60064, USA. HaiyingZhang@abbott.com, Haasch D, Patterson B, Dickinson B, Kifle L, Fry DG, Okasinski GF |
| Jazyk: |
angličtina |
| Zdroj: |
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 1999 Jul-Aug; Vol. 20 (4), pp. 193-201. |
| DOI: |
10.1159/000030063 |
| Abstrakt: |
CD80, a cell surface molecule found on antigen-presenting cells which particpates in costimulatory signaling, is frequently detected on transformed and tumor cells. We examined the effect of transformation by v-myc, k-ras, and SV40 T antigen oncogenes on the expression of a CD80 promoter/luciferase gene as well as the endogenous CD80 promoter gene in murine fibroblast cell lines. All three transformed cell lines were tumorigenic in nude mice, however expression of the CD80/luciferase transgene or endogenous CD80 was detected only in the v-myc and k-ras transformed cell lines. In both cell lines, CD80 expression was first detected more than 30 passages after transformation. Therefore, induction of CD80 expression was a late event following transformation and was not essential for the establishment of the transformed phenotype. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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