| Autor: |
Dmitrieva MN; Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia., Gruber IM, Gavrilova NA, Titova NG, Iakovleva IV, Sviridov VV |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1999 Mar-Apr (2), pp. 32-5. |
| Abstrakt: |
Direct correlation between the results of tests for the biological activity of diphtheria toxin, carried out in vivo guinea pigs and in vitro in the microcytotoxicity test in CHO cell culture, has been established, which makes it possible to use the latter as one of the methods for the rapid, reproducible and economic evaluation of diphtheria toxin. The qualitative and quantitative evaluation of diphtheria toxin in the enzyme immunoassay with the use of monoclonal antibodies and in the microcytotoxicity test demonstrates that these two tests, when used for controlling cultivation processes, have essential advantages over the flocculation test as regards their specificity and information content. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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