Zobrazeno 1 - 10
of 2 350
pro vyhledávání: '"zinc finger nuclease"'
Autor:
Suman Jyoti Bhuyan, Manoj Kumar, Pandurang Ramrao Devde, Avinash Chandra Rai, Amit Kumar Mishra, Prashant Kumar Singh, Kadambot H. M. Siddique
Publikováno v:
Frontiers in Genome Editing, Vol 5 (2023)
Genetic modifications are made through diverse mutagenesis techniques for crop improvement programs. Among these mutagenesis tools, the traditional methods involve chemical and radiation-induced mutagenesis, resulting in off-target and unintended mut
Externí odkaz:
https://doaj.org/article/7a2434a0d2734a7bb3b3689ce930986e
Autor:
Marion David, Davide Monteferrario, Gaëlle Saviane, Caroline Jeanneau, Irène Marchetti, Coralie F. Dupont, Céline Dumont, Jason D. Fontenot, Maurus de la Rosa, David Fenard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101111- (2023)
B cells can differentiate into plasmablast and plasma cells, capable of producing antibodies for decades. Gene editing using zinc-finger nucleases (ZFN) enables the engineering of B cells capable of secreting sustained and high levels of therapeutic
Externí odkaz:
https://doaj.org/article/0733b84714ce45809ca6ae4ad2effbc8
Autor:
Christopher W. Peterson, Rasika Venkataraman, Sowmya S. Reddy, Dnyanada Pande, Mark R. Enstrom, Stefan Radtke, Olivier Humbert, Hans-Peter Kiem
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 30-39 (2022)
Over the past decade, numerous gene-editing platforms which alter host DNA in a highly specific and targeted fashion have been described. Two notable examples are zinc finger nucleases (ZFNs), the first gene-editing platform to be tested in clinical
Externí odkaz:
https://doaj.org/article/914e78184e344cbbb56be4800d0999c1
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells rem
Externí odkaz:
https://doaj.org/article/d1ce988184354b54b4107b2f9529c336
Akademický článek
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Publikováno v:
The Journal of Reproduction and Development, Vol 67, Iss 3, Pp 177-187 (2021)
Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies. Owing to the similarity in the physiological traits of pig
Externí odkaz:
https://doaj.org/article/0ad8c633862e49638b333be4fbb71d9c
Autor:
Nafiseh Hosseini, Hossein Khanahmad, Bahram Nasr Esfahani, Mojgan Bandehpour, Laleh Shariati, Nushin Zahedi, Bahram Kazemi
Publikováno v:
Research in Pharmaceutical Sciences, Vol 15, Iss 2, Pp 182-190 (2020)
Background and purpose: The study was launched to use zinc finger nuclease (ZFN) technology to disrupt the cholera toxin gene (ctxA) for inhibiting CT toxin production in Vibrio cholera (V. cholera). Experimental approach: An engineered ZFN was desig
Externí odkaz:
https://doaj.org/article/3b75f8a3196a4df8b83d0f5bf9b0a76f
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-6 (2019)
Abstract Objectives Removal of selection marker genes from transgenic plants is highly desirable for their regulatory approval and public acceptance. This study evaluated the use of two nucleases, the yeast homing endonuclease, I-SceI, and the design
Externí odkaz:
https://doaj.org/article/881cbb2de6ef452f97f5a18a51b56d80
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2018 Sep . 115(38), 9351-9358.
Externí odkaz:
https://www.jstor.org/stable/26531119
Publikováno v:
同志社大学ハリス理化学研究報告 = The Harris science review of Doshisha University. 63(4):227-234
ジンクフィンガータンパク質は，ヒトプロテオーム中に豊富に存在し，様々な機能に関与している．ジンクフィンガータンパク質の生物学的重要性，その機能向上や生物学的応用を目的
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::84f93410fb230ea2b5ad9d73af9034b2
http://id.nii.ac.jp/1707/00029401/
http://id.nii.ac.jp/1707/00029401/