Zobrazeno 1 - 10
of 50
pro vyhledávání: '"zhong-zhen zhou"'
Publikováno v:
ACS Omega, Vol 4, Iss 17, Pp 17556-17560 (2019)
Externí odkaz:
https://doaj.org/article/81f33d1304064ec4a8f33675d651b569
Autor:
Pei-Liang Zhao, Zhong-Zhen Zhou
Publikováno v:
Acta Crystallographica Section E, Vol 65, Iss 8, Pp o2030-o2031 (2009)
The title molecule, C18H14N2O5S·C3H7NO, comprises of a carboxamide group bonded to a furan ring and a distorted envelope-shaped 4-oxothiazolidin-3-yl group which is connected to a substituted 6-methyl-4-oxo-4H-chromen-3-yl group. Extensive strong N
Externí odkaz:
https://doaj.org/article/0bfd88e197ad4dfba92ce4398dcd4113
Publikováno v:
European journal of medicinal chemistry. 238
Recently, the discovery of multifunctional molecules that target different factors in the treatment of dementia is a significant research area. Both PDE4 and AChE inhibitors display improvement in cognitive and memory function. In this study, twenty-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2657ae417a5710eef57bb3ec8d3de4
https://pubmed.ncbi.nlm.nih.gov/35689855
https://pubmed.ncbi.nlm.nih.gov/35689855
Autor:
Chuang Xia, Jia-Peng He, Kai-Wen Feng, Lu Liu, Lei Zheng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou
Publikováno v:
ACS chemical neuroscience. 13(3)
To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a0eb3a6e6f589078025155d136d470
https://pubmed.ncbi.nlm.nih.gov/35050567
https://pubmed.ncbi.nlm.nih.gov/35050567
Publikováno v:
European Journal of Medicinal Chemistry. 250:115194
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afbc47007d89eda7dacb6757612c230e
https://doi.org/10.1016/j.ejmech.2023.115194
https://doi.org/10.1016/j.ejmech.2023.115194
Publikováno v:
Bioorganic & Medicinal Chemistry. 73:117007
Nineteen TH03 analogues were designed and synthesized as tubulin colchicine-binding site inhibitors with potent antiproliferative activities. Among these compounds, 3,5-dimethoxyphenylpyridines 8j bearing a 4-methoxybenzyl aniline side-chain displaye
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e95c7971606dfcae059ae6596573d19
https://doi.org/10.1016/j.bmc.2022.117007
https://doi.org/10.1016/j.bmc.2022.117007
Autor:
Zhong-Zhen Zhou, Huizhen Wen, Rumeng Yao, Jiao Xiao, Jiangping Xu, Haitao Wang, Jiahong Zhong, Dan Li, Bingtian Xu
Publikováno v:
Cellular and Molecular Neurobiology. 40:421-435
Tumor necrosis factor-α (TNF-α) is a critical pro-inflammatory cytokine regulating neuroinflammation. At high concentrations, it is toxic to neurons, and such damage is positively correlated with acute and chronic neurological diseases. Our previou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6b86ae9f199e1490f5da24d3ef611
https://doi.org/10.1007/s10571-019-00745-w
https://doi.org/10.1007/s10571-019-00745-w
Autor:
Huizhen Wen, Jinfeng Xie, Jiangping Xu, Haitao Wang, Jiahong Zhong, Bingtian Xu, Zhong-Zhen Zhou, Dan Li, Jiao Xiao, Xinyi Wang, Yufang Cheng
Publikováno v:
Free Radical Biology and Medicine. 135:87-101
The etiology of Parkinson's disease (PD) is generally not well understood, but it is believed to involve excessive oxidative insult. Hence, identifying therapeutic targets and compounds that exhibit protective effects against oxidative damage is a re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee128983970b1499c9dbc1564c0bc866
https://doi.org/10.1016/j.freeradbiomed.2019.02.027
https://doi.org/10.1016/j.freeradbiomed.2019.02.027
Autor:
Jiayin Guo, Menghua Liu, JiaPeng He, Chang Huang, Jiahong Zhong, Zhong-Zhen Zhou, Jiangping Xu, Haitao Wang, Lv Tang
Publikováno v:
European Journal of Medicinal Chemistry. 168:221-231
Growing evidence confirms the potential of PDE4 inhibitors for the treatment of Parkinson's disease. Our reported PDE4 inhibitors FCPR16 and FCPR03 have displayed neuroprotective effects in SH-SY5Y cells, but have very low oral bioavailability. To ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7304a2ba190b39944d0e4455854decea
https://doi.org/10.1016/j.ejmech.2019.02.026
https://doi.org/10.1016/j.ejmech.2019.02.026
Publikováno v:
European journal of medicinal chemistry. 224
To discover PDE4/tubulin dual inhibitors with novel skeleton structures, 7-trimethoxyphenylbenzo[d]oxazoles 4a-u and 4-trimethoxyphenylbenzo[d]oxazoles 5a-h were designed and synthesized by migrating the trimethoxyphenyl group of TH03 to the benzo[d]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd30b415c0c8182cd60a6cf90810ea2a
https://pubmed.ncbi.nlm.nih.gov/34311158
https://pubmed.ncbi.nlm.nih.gov/34311158