Výsledky vyhledávání - "zhong-zhen zhou"

Discovery of novel 2,3-dihydro-1H-inden-1-ones as dual PDE4/AChE inhibitors with more potency against neuroinflammation for the treatment of Alzheimer's disease

Autor: Jie Liu, Lu Liu, Lei Zheng, Kai-Wen Feng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou

Publikováno v: European journal of medicinal chemistry. 238

Recently, the discovery of multifunctional molecules that target different factors in the treatment of dementia is a significant research area. Both PDE4 and AChE inhibitors display improvement in cognitive and memory function. In this study, twenty-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da2657ae417a5710eef57bb3ec8d3de4
https://pubmed.ncbi.nlm.nih.gov/35689855

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Discovery of Novel 3-Amino-4-alkoxyphenylketones as PDE4 Inhibitors with Improved Oral Bioavailability and Safety against Spatial Memory Impairments

Autor: Chuang Xia, Jia-Peng He, Kai-Wen Feng, Lu Liu, Lei Zheng, Hai-Tao Wang, Jiang-Ping Xu, Zhong-Zhen Zhou

Publikováno v: ACS chemical neuroscience. 13(3)

To realize PDE4 inhibitors with good developmental potentiality for the treatment of dementia, structure-based optimizations of lead compound FCPR03 resulted in novel aminophenylketones

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a0eb3a6e6f589078025155d136d470
https://pubmed.ncbi.nlm.nih.gov/35050567

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Discovery of polymethoxyphenyl-pyridines bearing amino side chains as tubulin colchicine-binding site inhibitors

Autor: XiaoYang Li, HuanXian Wu, Kai-Wen Feng, JiaHuan Xu, Shaoyu Wu, zhong-zhen zhou, Xiao-Fang Li

Publikováno v: Bioorganic & Medicinal Chemistry. 73:117007

Nineteen TH03 analogues were designed and synthesized as tubulin colchicine-binding site inhibitors with potent antiproliferative activities. Among these compounds, 3,5-dimethoxyphenylpyridines 8j bearing a 4-methoxybenzyl aniline side-chain displaye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e95c7971606dfcae059ae6596573d19
https://doi.org/10.1016/j.bmc.2022.117007

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Inhibition of PDE4 Attenuates TNF-α-Triggered Cell Death Through Suppressing NF-κB and JNK Activation in HT-22 Neuronal Cells

Autor: Zhong-Zhen Zhou, Huizhen Wen, Rumeng Yao, Jiao Xiao, Jiangping Xu, Haitao Wang, Jiahong Zhong, Dan Li, Bingtian Xu

Publikováno v: Cellular and Molecular Neurobiology. 40:421-435

Tumor necrosis factor-α (TNF-α) is a critical pro-inflammatory cytokine regulating neuroinflammation. At high concentrations, it is toxic to neurons, and such damage is positively correlated with acute and chronic neurological diseases. Our previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66c6b86ae9f199e1490f5da24d3ef611
https://doi.org/10.1007/s10571-019-00745-w

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Inhibition of PDE4 by FCPR16 induces AMPK-dependent autophagy and confers neuroprotection in SH-SY5Y cells and neurons exposed to MPP+-induced oxidative insult

Autor: Huizhen Wen, Jinfeng Xie, Jiangping Xu, Haitao Wang, Jiahong Zhong, Bingtian Xu, Zhong-Zhen Zhou, Dan Li, Jiao Xiao, Xinyi Wang, Yufang Cheng

Publikováno v: Free Radical Biology and Medicine. 135:87-101

The etiology of Parkinson's disease (PD) is generally not well understood, but it is believed to involve excessive oxidative insult. Hence, identifying therapeutic targets and compounds that exhibit protective effects against oxidative damage is a re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee128983970b1499c9dbc1564c0bc866
https://doi.org/10.1016/j.freeradbiomed.2019.02.027

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Discovery of arylbenzylamines as PDE4 inhibitors with potential neuroprotective effect

Autor: Jiayin Guo, Menghua Liu, JiaPeng He, Chang Huang, Jiahong Zhong, Zhong-Zhen Zhou, Jiangping Xu, Haitao Wang, Lv Tang

Publikováno v: European Journal of Medicinal Chemistry. 168:221-231

Growing evidence confirms the potential of PDE4 inhibitors for the treatment of Parkinson's disease. Our reported PDE4 inhibitors FCPR16 and FCPR03 have displayed neuroprotective effects in SH-SY5Y cells, but have very low oral bioavailability. To ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7304a2ba190b39944d0e4455854decea
https://doi.org/10.1016/j.ejmech.2019.02.026

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Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells

Autor: Jie liu, Zhong-Zhen Zhou, Jiangping Xu, Haitao Wang, Xiao-Fang Li, Wan Ye, Wen-Ya Wang

Publikováno v: European journal of medicinal chemistry. 224

To discover PDE4/tubulin dual inhibitors with novel skeleton structures, 7-trimethoxyphenylbenzo[d]oxazoles 4a-u and 4-trimethoxyphenylbenzo[d]oxazoles 5a-h were designed and synthesized by migrating the trimethoxyphenyl group of TH03 to the benzo[d]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd30b415c0c8182cd60a6cf90810ea2a
https://pubmed.ncbi.nlm.nih.gov/34311158

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Synthesis, Biological Evaluation, and Molecular Docking of Arylpyridines as Antiproliferative Agent Targeting Tubulin

Autor: JiaPeng He, Jie liu, Wen-Ya Wang, Jiangping Xu, Haitao Wang, Mao Zhang, Jiahong Zhong, Xiao-Fang Li, Lv Tang, Zhong-Zhen Zhou

Publikováno v: ACS Med Chem Lett

[Image: see text] Mimicking different pharmacophoric units into one scaffold is a promising structural modification tool to design new drugs with enhanced biological properties. To continue our research on the tubulin inhibitors, the synthesis and bi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de3022a0202c5a29906b8d15e247059
https://pubmed.ncbi.nlm.nih.gov/32832031

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