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Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats

Autor: Hatip-Al-Khatib, İzzettin, Iwasaki, K., Yoshimitsu, Y., Arai, T., Egashira, N., Mishima, K., Ikeda, T.

Zanapezil (TAK-147 (3-[1benzylpiperdin-4-yl]-1-(2,3,4,5-tetrahydro-1 H-1-benzazepin-8-yl) propan-1-one fumarate)) is a selective acetylcholine (ACh) esterase inhibitor under investigation as a drug for Alzheimer's disease (AD) treatment. In this stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_____10652::0e401a5cbb93459af911d73c2d7dde12
https://hdl.handle.net/11499/4749

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Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats

Autor: Hatip-Al-Khatib I, Iwasaki K, Yoshimitsu Y, Arai T, Egashira N, Mishima K, Ikeda T, Fujiwara M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::920b508d78c0f6fe5d98d4cdfbd66213
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4749

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Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats

Autor: Arai Takashi, Katsunori Iwasaki, Izzettin Hatip-Al-Khatib, Nobuaki Egashira, Michihiro Fujiwara

The effects of zanapezil (TAK-147) and donepezil (E2020) on extracellular acetylcholine (ACh) levels were investigated by HPLC-microdialysis of ventral hippocampus (VH) in freely moving intact rats. The results showed that the basal ACh release rate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2ecd4e43b346f6effbadb7b7830e65
http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/5088

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