Methylated Cytochrome P450 and the Solute Carrier Family of Genes Correlate With Perturbations in Bile Acid Metabolism in Parkinson’s Disease

Autor: Sangeetha Vishweswaraiah, Sumeyya Akyol, Ali Yilmaz, Zafer Ugur, Juozas Gordevičius, Kyung Joon Oh, Patrik Brundin, Uppala Radhakrishna, Viviane Labrie, Stewart F. Graham

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Parkinson’s disease (PD) is second most prevalent neurodegenerative disorder following Alzheimer’s disease. Parkinson’s disease is hypothesized to be caused by a multifaceted interplay between genetic and environmental factors. Herein, and for

Externí odkaz: https://doaj.org/article/4e5cb75fdff04f49bba0fcfc9dbc0b47

Metabolic Profiling of CSF from People Suffering from Sporadic and LRRK2 Parkinson’s Disease: A Pilot Study

Autor: Ali Yilmaz, Zafer Ugur, Ilyas Ustun, Sumeyya Akyol, Ray O. Bahado-Singh, Michael Maddens, Jan O. Aasly, Stewart F. Graham

Publikováno v: Cells, Vol 9, Iss 11, p 2394 (2020)

CSF from unique groups of Parkinson’s disease (PD) patients was biochemically profiled to identify previously unreported metabolic pathways linked to PD pathogenesis, and novel biochemical biomarkers of the disease were characterized. Utilizing bot

Externí odkaz: https://doaj.org/article/271de77f580c4175a68e23da7922feda

The Biochemical Profile of Post-Mortem Brain from People Who Suffered from Epilepsy Reveals Novel Insights into the Etiopathogenesis of the Disease

Autor: Ashna M. Lalwani, Ali Yilmaz, Halil Bisgin, Zafer Ugur, Sumeyya Akyol, Stewart Francis Graham

Publikováno v: Metabolites, Vol 10, Iss 6, p 261 (2020)

Epilepsy not-otherwise-specified (ENOS) is one of the most common causes of chronic disorders impacting human health, with complex multifactorial etiology and clinical presentation. Understanding the metabolic processes associated with the disorder m

Externí odkaz: https://doaj.org/article/d29af9481c804b17bd4fc43cb70d3330

Metabolomic Profiling of Bile Acids in an Experimental Model of Prodromal Parkinson’s Disease

Autor: Stewart F. Graham, Nolwen L. Rey, Zafer Ugur, Ali Yilmaz, Eric Sherman, Michael Maddens, Ray O. Bahado-Singh, Katelyn Becker, Emily Schulz, Lindsay K. Meyerdirk, Jennifer A. Steiner, Jiyan Ma, Patrik Brundin

Publikováno v: Metabolites, Vol 8, Iss 4, p 71 (2018)

For people with Parkinson’s disease (PD), considered the most common neurodegenerative disease behind Alzheimer’s disease, accurate diagnosis is dependent on many factors; however, misdiagnosis is extremely common in the prodromal phases of the d

Externí odkaz: https://doaj.org/article/0003ce4bbc2641999a3bd8d919795571

Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism

Autor: Bernadette McGuinness, Michael Maddens, Patrick G. Kehoe, Peter Passmore, Santosh Kapil Kumar Gorti, Brian D. Green, Stewart F. Graham, Ilyas Ustun, Kyungjoon Oh, Sumeyya Akyol, Ali Yilmaz, Zafer Ugur

Publikováno v: Akyol, S, Ugur, Z, Yilmaz, A, Ustun, I, Gorti, S K K, Oh, K, McGuinness, B, Passmore, P, Kehoe, P G, Maddens, M E, Green, B D & Graham, S F 2021, ' Lipid Profiling of Alzheimer’s Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism ', Cells, vol. 10, no. 10, 2591 . https://doi.org/10.3390/cells10102591
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2591, p 2591 (2021)

Alzheimer’s disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its subsequent development, we profiled the lipidome of postmortem (PM) human brains (neocort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e066e3bfe5f063a32dd6607f052061
https://pure.qub.ac.uk/en/publications/lipid-profiling-of-alzheimers-disease-brain-highlights-enrichment-in-glycerolphospholipid-and-sphingolipid-metabolism(d540628a-9ac2-40ea-b443-85965feac9d0).html