Výsledky vyhledávání - "z S, Smirnova"

CREATING LABORATORY TECHNOLOGY OF GENERIC EPIRUBICIN PHARMECEUTICAL DOSAGE FORM

Autor: S. V. Kohachevskaya, L. M. Borisova, M. P. Kiseleva, T. Y. Eskina, Y. V. Rodionova, Z. S. Smirnova, Z. S. Shprakh, A. P. Polozkova, O. L. Orlova, N. A. Oborotova, M. V. Dmitrieva

Publikováno v: Russian Journal of Biotherapy. 15:72-77

Introduction. Governments around the world seek to reduce rapidly rising health care costs. Using the same high quality and often cheaper than the original brands, generics greatly reduces costs while providing an adequate quality of care. Therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5f808da38f1d1a8a974894d3321934f
https://doi.org/10.17650/1726-9784-2016-15-4-72-77

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Antitumor activity of Ormustine against transplanted leukemia in mice

Autor: M. M. Davydov, Z. S. Smirnova, L. M. Borisova, Galina L. Levit, M. P. Kiseleva, Victor P. Krasnov, Z. S. Shprakh, V. M. Bukhman, Vera V. Musiyak, M. A. Baryshnikova, N. S. Saprykina

Publikováno v: Russian Journal of Biotherapy. 15:24-31

Objective: Evaluation of antitumor activity of a novel alkylnitrosoureas derivative Ormustine (an alkylnitrosocarbamoyl L-ornithine) in mouse lymphoid leukemia models. Materials and methods Antitumor activity of Ormustine has been evaluated in B6D2F1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47349686f477caa4b26ba056d883f81f
https://doi.org/10.17650/1726-9784-2016-15-2-24-31

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DEVELOPING A MODEL OF LIPOSOMAL FORMULATION OF A NEW NATIONAL ANALOGUE HYPOTHALAMIC HORMONE SOMATOSTATIN, WHICH HAS ANTI-TUMOR ACTIVITY

Autor: O. L. Orlova, M. P. Kiseleva, N. A. Oborotova, Xi Zhang, L. M. Borisova, Z. S. Shprakh, Z. S. Smirnova, E. V. Sanarova, M. V. Dmitrieva, A. P. Polozkova, A. V. Lantsova

Publikováno v: Russian Journal of Biotherapy. 14:73-78

At present, the hormone somatostatin analogues is increasing interest in connection with their activity against hormone-dependent tumors, which leads to the need to develop domestic drugs belonging to this group. In the laboratory of chemical synthes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a89e1c13c8a4c4fd4302cf16de0555c1
https://doi.org/10.17650/1726-9784-2015-14-4-73-78

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PRECLINICAL STUDY OF INDOLOCARBAZOLES N-GLYCOSIDES DERIVATIVE LCS-1208 ANTITUMOR ACTIVITY. REPORT I

Autor: L. M. Borisova, A. Yu. Baryshnikov, Z. S. Shprakh, I. Yu. Kubasova, Z. S. Smirnova, N. A. Oborotova, E. V. Sanarova, A. V. Lantsova, M. P. Kiseleva

Publikováno v: Russian Journal of Biotherapy. 14:71-77

This article presents the results of preclinical study of antitumor activity of indolo[2,3-a]carbazoles N-glycosides derivative (LCS-1208) in pharmaceutical dosage form for intravenous administration - lyophilisate for injection. LCS-1208 high antitu

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https://doi.org/10.17650/1726-9784-2015-14-2-71-77

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Near-infrared photosensitizers based on nanostructured forms of phthalocyanine derivatives

Autor: Z. S. Smirnova, Vorozhtsov Gn, L. M. Borisova, A. P. Polozkova, N. A. Oborotova, G. A. Meerovich, Valentina M. Derkacheva, A. Yu. Baryshnikov, O. L. Orlova, K. A. Volkov, S. V. Barkanova, Evgeny A. Lukyanets, I. G. Meerovich, Victor B. Loschenov, E. V. Sanarova, A. V. Lantsova, L. V. Umnova, V. M. Negrimovsky

Publikováno v: Russian Journal of General Chemistry. 85:280-288

The research is devoted to development and study of photosensitizers on a base of injectable nanoparticular formulations of phthalocyanine derivatives absorbing at long wavelength (near-infrared) range of 710–740 nm: Thiosens [liposomal form of alu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b863d71dd213c6646c622201066a300d
https://doi.org/10.1134/s1070363215010430

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Thiosens liposomal dosage form technology development and photodynamic efficiency assessment

Autor: E. Lukyanets, Gennady A. Meerovich, A. P. Polozkova, E. A. Kotova, Z. S. Smirnova, A. V. Lantsova, Z. S. Shprakh, N. A. Oborotova, L. M. Borisova, E. V. Sanarova, I. G. Meerovich, A. Baryshnikov, O. L. Orlova

Publikováno v: Journal of Drug Delivery Science and Technology. 24:315-319

Authors have developed the composition, technology of preparation, dosage form and sucrose-protected lyophilization protocol for formulation for systemic administration of near-infrared range photosensitizer thiosens based on PEG-liposomal formulatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::508d307a097beb7206803b88813ccc93
https://doi.org/10.1016/s1773-2247(14)50068-8

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Antiproliferative Activity of a New Nitrosyl Iron Complex with Cysteamine in Human Tumor Cells In Vitro

Autor: I O Chikileva, Z S Smirnova, O S Zhukova, M. V. Kiselevskii

Publikováno v: Bulletin of experimental biology and medicine. 162(4)

We studied cytotoxic activity of a new NO-releasing tetranitrosyl binuclear iron complex with cysteamine (CysAm) for human tumor cells, the relationship between the expression of O6-methylguanine-DNA methyltransferase (MGMT) and cell sensitivity to C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b632150af1cfc5beb50fafdff4c1b5
https://pubmed.ncbi.nlm.nih.gov/28239795

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Search for new drugs

Autor: Z. S. Smirnova, T. A. Titova, B. I. Keda, V. M. Rzheznikov, L. E. Golubovskaya, V. N. Tolkachev, L. P. Sushinina

Publikováno v: Pharmaceutical Chemistry Journal. 43:601-605

Analogs of 11β-hydroxyestrone and 17α-ethynylestradiol with a cytotoxic bis-(2-chloroethyl)amino-containing substituent were synthesized in two principal steps from the corresponding 11-hydroxysteroids. Introduction of this bulky fragment influence

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https://doi.org/10.1007/s11094-010-0361-5

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Novel Antitumor L-Arabinose Derivative of Indolocarbazole with High Affinity to DNA

Autor: Dmitry N. Kaluzhny, Ghermes G. Chilov, Fedor N. Novikov, Irina L. Plikhtyak, Lyubov G. Dezhenkova, Anna K. Shchyolkina, Olga F. Borisova, M. A. Livshits, Victor V. Tatarskiy, Alexander A. Shtil, Stalina Ya. Mel'nik, Strel'tsov Sa, Z. S. Smirnova, Tatyana D. Miniker, Irina Yu. Kubasova

Publikováno v: ChemMedChem. 4:1641-1648

Novel indolocarbazole derivative 12-(alpha-L-arabinopyranosyl)indolo[2,3-alpha]pyrrolo[3,4-c]carbazole-5,7-dione (AIC) demonstrated high potency (at submicromolar concentrations) against the NCI panel of human tumor cell lines and transplanted tumors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aaf39a36e149945aae8bf0e77accf78
https://doi.org/10.1002/cmdc.200900227

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