Zobrazeno 1 - 10
of 3 348
pro vyhledávání: '"yes-associated protein"'
Publikováno v:
Zhongguo Linchuang Yixue, Vol 31, Iss 5, Pp 772-777 (2024)
ObjectiveTo explore the expression and clinical significance of Yes-associated protein 1 (YAP1) in esophageal squamous cell carcinoma. MethodsImmunohistochemical method was used to detect YAP1 expression in 439 cases of esophageal squamous cell carci
Externí odkaz:
https://doaj.org/article/4a7a806dabb0478998568c05abecf43a
Publikováno v:
Jichu yixue yu linchuang, Vol 44, Iss 9, Pp 1243-1248 (2024)
Objective To investigate the effect of remimazolam (RE) on myocardial injury in myocardial ischemia-reperfusion (MI/R) rats and its mechanism. Methods The MI/R rat model was constructed and divided into sham group, MI/R model group, RE low, medium, h
Externí odkaz:
https://doaj.org/article/d4f5540683044548bbb2a3d02739221d
Publikováno v:
Pharmaceutical Biology, Vol 62, Iss 1, Pp 314-325 (2024)
AbstractContext Cholangiocarcinoma with highly heterogeneous, aggressive, and multidrug resistance has a poor prognosis. Although babaodan (BBD) combined with cisplatin improved non-small cell lung cancer efficacy, its impact on overcoming resistance
Externí odkaz:
https://doaj.org/article/a96da55d19d546319231697d091f54a3
Publikováno v:
Diabetes, Metabolic Syndrome and Obesity, Vol Volume 17, Pp 3197-3214 (2024)
Caige Li,1,2 Yu Xue,1 Yiwei Liu,1 Kangning Zheng,1 Yuting Gao,1,3 Yi Gong,1 Junlan Lu,1 Yuman Zhang,1 Jingmin Ji,1 Zhiqin Zhang,1 Xinli Shi1 1Department of Pathobiology and Immunology, Hebei University of Chinese Medicine, Shijiazhuang, Hebei, People
Externí odkaz:
https://doaj.org/article/98a8f6aaf1df4af992dd628129da80c3
Publikováno v:
陆军军医大学学报, Vol 46, Iss 12, Pp 1403-1409 (2024)
Objective To explore the role of sulodexide (SDX) in neointimal hyperplasia of arteriovenous fistulas (AVFs) in chronic kidney disease (CKD) rats and its possible mechanism. Methods A total of 18 male rats (weighing 300±50 g) were randomly and equal
Externí odkaz:
https://doaj.org/article/bce9ed08bbe84d71856df2b0eed134f1
Autor:
Mei Wang, Wanjun Yu, Xiaoli Cao, Hongbing Gu, Jiaying Huang, Chen Wu, Lin Wang, Xin Sha, Bo Shen, Ting Wang, Yongliang Yao, Wei Zhu, Feng Huang
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/2cd9316250224d5f8189d2d703fc64da
Autor:
Ruiyang Ma, Huanjing Bi, Ying Wang, Jingwen Wang, Jiangwei Zhang, Xiaoyang Yu, Zuhan Chen, Jiale Wang, Cuinan Lu, Jin Zheng, Yang Li, Xiaoming Ding
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-18 (2024)
Abstract Optimizing the efficiency of definitive endoderm (DE) differentiation is necessary for the generation of diverse organ-like structures. In this study, we used the small molecule inhibitor saracatinib (SAR) to enhance DE differentiation of hu
Externí odkaz:
https://doaj.org/article/b2d0dbd19811407d92e530016627af80
Autor:
Lina Zhang, Xinxing Wang, Guang Xia, Junjie Huang, Zi Wen, Chi Liang, Xu Cao, Yong Zhou, Song Wu
Publikováno v:
Journal of Orthopaedic Translation, Vol 46, Iss , Pp 79-90 (2024)
Background: The cartilage stem/progenitor cells (CSPC) play a critical role in maintaining cartilage homeostasis. However, the effects of phenotypic fluctuations of CSPC on cartilage degeneration and the role of CSPC in the pathogenesis of OA is larg
Externí odkaz:
https://doaj.org/article/bce7bded224343d18a07dc6d03f6ab02
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is one of the most prevalent renal cancers, and the molecular mechanisms underlying its progression are still not fully understood. The expression of CCDC25, a notably underexpressed gene in
Externí odkaz:
https://doaj.org/article/9a721265a26e4c20a303beea86ebece9
Autor:
Paipai Guo, Ji Jiang, Rui Chu, Feng He, Mingli Ge, Ruhong Fang, Qiuyun Guan, Huijuan Cheng, Chunru Jiang, Tiantian Su, Zhenduo Zhu, Hao Liu, Wei Wei, Shihao Zhang, Qingtong Wang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 3, Pp 1222-1240 (2024)
Hyperplasia and migration of fibroblast-like synoviocytes (FLSs) are the key drivers in the pathogenesis of rheumatoid arthritis (RA) and joint destruction. Abundant Yes-associated protein (YAP), which is a powerful transcription co-activator for pro
Externí odkaz:
https://doaj.org/article/6c0300bb6c90479aada92d8108f3892f