Zobrazeno 1 - 10
of 737
pro vyhledávání: '"xianjun yu"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 3634-3650 (2024)
Gemcitabine is a standard first-line drug for pancreatic cancer chemotherapy. Nevertheless, gemcitabine resistance is common and significantly limits its therapeutic efficacy, impeding advancements in pancreatic cancer treatment. In this study, throu
Externí odkaz:
https://doaj.org/article/977c18f132574aa0a690046006ab5d02
Autor:
Rong Tang, Zifeng Zhang, Jin Xu, Wei Wang, Qingcai Meng, Yuan Liu, Qiong Du, Chen Liang, Jie Hua, Bo Zhang, Xianjun Yu, Si Shi
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 1689-1704 (2024)
Background: Mounting evidence underscores the importance of cell communication within the tumor microenvironment, which is pivotal in tumor proliferation, invasion, and metastasis. Exosomes play a crucial role in cell-to-cell communication. Although
Externí odkaz:
https://doaj.org/article/a7c01f957d71404990cf4a4033cc6d8f
Autor:
Heli Gao, Wuhu Zhang, Zheng Li, Wensheng Liu, Mengqi Liu, Qifeng Zhuo, Yihua Shi, Wenyan Xu, Chenjie Zhou, Yi Qin, Jin Xu, Jie Chen, Xianjun Yu, Xiaowu Xu, Shunrong Ji
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Ki67 index changes during the treatment of metastatic pancreatic neuroendocrine tumor (PanNET) treatment. The study aimed to detect alterations of grade based on Ki67 index and immune microenvironment in PanNET responding to capec
Externí odkaz:
https://doaj.org/article/07be9ba86f7a4a8dbe7f208d56ee4cc4
Autor:
Miaoyan Wei, Rujiao Liu, Yunyun Xu, Xiaobing Chen, Chao Liu, Xueli Bai, Xiaochen Zhang, Shuiping Gao, Jialin Li, Zhen Sheng, Jianpo Lian, Wenliang Wang, Jian Zhang, Si Shi, Jin Xu, Xianjun Yu
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-11 (2024)
Abstract Background Chemotherapy remains the standard first-line treatment for pancreatic adenocarcinoma, but with limited efficacy. We aimed to explore the feasibility of adding the PARP inhibitor fuzuloparib to mFOLFIRINOX in the locally advanced/m
Externí odkaz:
https://doaj.org/article/cef3d052c08f444f99a82d9527d12961
Autor:
Mingming Xiao, Jing Yang, Mingwei Dong, Xiaoqi Mao, Haoqi Pan, Yalan Lei, Xuhui Tong, Xiaoning Yu, Xianjun Yu, Si Shi
Publikováno v:
Cell Death and Disease, Vol 15, Iss 8, Pp 1-16 (2024)
Abstract Olaparib has been approved as a therapeutic option for metastatic pancreatic ductal adenocarcinoma patients with BRCA1/2 mutations. However, a significant majority of pancreatic cancer patients have inherent resistance or develop tolerance t
Externí odkaz:
https://doaj.org/article/67c593f6585e478c9e65fdc330dcf273
Publikováno v:
Autophagy Reports, Vol 3, Iss 1 (2024)
Olaparib has been approved as a treatment for metastatic pancreatic ductal adenocarcinoma in patients with BRCA1 (BRCA1 DNA repair associated) or BRCA2 mutations. However, a large portion of pancreatic cancer patients either exhibit inherent resistan
Externí odkaz:
https://doaj.org/article/f6b4834e21e04e7d859f468936326781
Autor:
Jie Chen, Wenming Wu, Chunmei Bai, Yihebali Chi, Li Huo, Liming Jiang, Yuan Ji, Jie Luo, Jie Li, Jingnan Li, Wenhui Lou, Chenghao Shao, Lin Shen, Feng Wang, Yu Wang, Ling Xue, Jin Xu, Chunhui Yuan, Xianjun Yu, Xiaoyu Yin, Hong Zhao, Xiongzeng Zhu, Yupei Zhao
Publikováno v:
Journal of Pancreatology, Vol 7, Iss 2, Pp 97-105 (2024)
The World Health Organization (WHO) 2017 classifications for neuroendocrine neoplasms (NENs) subdivided grade 3 pancreatic neuroendocrine neoplasms (pNENs) into G3 well-differentiated pancreatic neuroendocrine tumors (G3 pNETs) and poorly differentia
Externí odkaz:
https://doaj.org/article/f421cf90587443f5bc5768b80042928d
Autor:
Sichun Zhao, Fudie Guo, Yonghui Zang, Rong Hu, Xianjun Yu, Hongmei Zhang, Tingting Xie, Xiaoya Li, Chunxia Bai, Haoran Shi, Dingwei Zhang
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
BackgroundDiabetic foot ulcers (DFUs) are severe complications of diabetes, involving multiple etiological factors including neuropathy, vascular insufficiency, and impaired wound healing. The global burden of DFUs is substantial, with significant mo
Externí odkaz:
https://doaj.org/article/533fe791147c486480e63bfe5f548a0e
Autor:
Junfeng Xu, Xin Lou, Fei Wang, Wuhu Zhang, Xiaowu Xu, Zeng Ye, Qifeng Zhuo, Yan Wang, Desheng Jing, Guixiong Fan, Xuemin Chen, Yue Zhang, Chenjie Zhou, Jie Chen, Yi Qin, Xianjun Yu, Shunrong Ji
Publikováno v:
Advanced Science, Vol 11, Iss 35, Pp n/a-n/a (2024)
Abstract O6‐methylguanine DNA methyltransferase (MGMT) removes alkyl adducts from the guanine O6 position (O6‐MG) and repairs DNA damage. High MGMT expression results in poor response to temozolomide (TMZ). However, the biological importance of M
Externí odkaz:
https://doaj.org/article/b9de0dc9db3b4166a7eac67e8116e9ed
Autor:
Qin Dang, Borui Li, Bing Jin, Zeng Ye, Xin Lou, Ting Wang, Yan Wang, Xuan Pan, Qiangsheng Hu, Zheng Li, Shunrong Ji, Chenjie Zhou, Xianjun Yu, Yi Qin, Xiaowu Xu
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-22 (2024)
Abstract For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical transformation has gradually embarked on immunometabolism to the center stage of innate and adaptive
Externí odkaz:
https://doaj.org/article/4f69a13e8cb647ed8701a321ece4ee74