Zobrazeno 1 - 10
of 3 696
pro vyhledávání: '"xbp1"'
Autor:
Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu
Publikováno v:
Thoracic Cancer, Vol 15, Iss 29, Pp 2116-2127 (2024)
Abstract Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR). IRE1 reduces ER stress by upregulat
Externí odkaz:
https://doaj.org/article/f859a746fa45469598e66592e078d9f1
Autor:
Sadaf Bahadori, Zahra Farzaneh, Roya Solhi, Zahra Hajilou, Bahare Shokoohian, Moustapha Hassan, Mustapha Najimi, Massoud Vosough
Publikováno v:
Cell Journal, Vol 26, Iss 8, Pp 505-514 (2024)
Objective: The spliced form of X-box binding protein 1 (XBP1s) is a key transcription factor in the unfolded proteinresponse (UPR), an adaptive mechanism for cell survival. Many studies demonstrated the induced expression ofXBP1s in various cancers,
Externí odkaz:
https://doaj.org/article/e0f1c834cfa34e36956f3934297e4b38
Autor:
Yun Zhang, Susan Lin, Jing Yao, Wantong Cai, Huaqiu Chen, Ailikemu Aierken, Zhe Wang, Weihong Song
Publikováno v:
Genes and Diseases, Vol 11, Iss 5, Pp 101148- (2024)
As a pathological hallmark of type 2 diabetes mellitus (T2DM), islet amyloid is formed by the aggregation of islet amyloid polypeptide (IAPP). Endoplasmic reticulum (ER) stress interacts with IAPP aggregates and has been implicated in the pathogenesi
Externí odkaz:
https://doaj.org/article/8527f4bb162941a4974f9283ef5f1521
Autor:
Tiancheng Hu, Yiping Liu, Jeremy Fleck, Cason King, Elaine Schalk, Zhenyu Zhang, Andrew Mehle, Judith A. Smith
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in responses to “sterile” endogenous threats and pathogens without nominal DNA or cyclic di-nucleotide stimuli. Previous work showed an endoplasmic reticulum (ER) stres
Externí odkaz:
https://doaj.org/article/9edb2198c6ea41b3861f589b52b66b8d
Autor:
Yifan Hong, Xiazhu Zhou, Qi Li, Jing Chen, Yuexin Wei, Chunlan Long, Lianju Shen, Xiangqin Zheng, Dinggang Li, Xia Wang, Chenjun Yu, Shengde Wu, Guanghui Wei
Publikováno v:
Genes and Diseases, Vol 11, Iss 2, Pp 935-951 (2024)
As a widely used plasticizer, di-(2-ethylhexyl) phthalate (DEHP) is known to induce significant testicular injury. However, the potential mechanism and effects of pubertal exposure to DEHP on testis development remain unclear. In vivo, postnatal day
Externí odkaz:
https://doaj.org/article/04f529f728854105b736930900f8b23f
Autor:
Yifei Sun, Yihan Zhang, Jifeng Zhang, Y. Eugene Chen, Jian-Ping Jin, Kezhong Zhang, Hongmei Mou, Xiubin Liang, Jie Xu
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Sodium-Glucose cotransporter 1 and 2 (SGLT1/2) belong to the family of glucose transporters, encoded by SLC5A1 and SLC5A2, respectively. SGLT2 is almost exclusively expressed in the renal proximal convoluted tubule cells. SGLT1 is
Externí odkaz:
https://doaj.org/article/7d356fd837f148bf9a2f5e322faec115
Akademický článek
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Autor:
Haining Du, Jiaxin Li, Xiangjuan Wei, Daqian Yang, Boya Zhang, Xingpei Fan, Meimei Zhao, Ruijiao Zhu, Ziyi Zhang, Yuxia Zhang, Xiaoyan Li, Ning Gu
Publikováno v:
Environment International, Vol 184, Iss , Pp 108445- (2024)
Methylparaben (MP), a preservative widely used in daily supplies, exists in both the environment and the human body. However, the potential health risks posed by MP remain unclear. This study aimed to unravel the mechanisms by which MP disrupts gluco
Externí odkaz:
https://doaj.org/article/47f5c7d9e7024f14b121ea8a63e1e4e9
Autor:
Jianhua Rao, Zeng Wang, Fei Yu, Junda Li, Wenzhu Li, Zhengfeng Xuan, Yongquan Chi, Feng Zhang, Liming Tang, Feng Cheng
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 6, Pp 101402- (2024)
Background & Aims: XBP1, most conserved transcription factor of endoplasmic reticulum stress, plays important roles in physiological and pathologic settings and has profound effects on disease progression and prognosis, so it is necessary to investig
Externí odkaz:
https://doaj.org/article/b74a0ad4da874387b91d8ea5c6a6b1a5
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Upon endoplasmic reticulum (ER) stress, inositol-requiring enzyme 1 (IRE1) is activated, which subsequently converts an unspliced X-box binding protein 1 (XBP1U) mRNA to a spliced mRNA that encodes a potent XBP1S transcription factor. XBP1S is essent
Externí odkaz:
https://doaj.org/article/1eb9e54e55c342da9f76fc15e2aaa8b0