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Identification of Potential Human Ryanodine Receptor 1 Agonists and Molecular Mechanisms of Natural Small-Molecule Phenols as Anxiolytics

Autor: Yahong Chen, Haifeng Zhai, Jianmei Huang, Xiaohong Wang, Yanling Zhang

Publikováno v: ACS Omega
ACS Omega, Vol 6, Iss 44, Pp 29940-29954 (2021)

Natural small-molecule phenols (NSMPs) possess certain ubiquitous bioactivities including the anxiolytic effect. Ryanodine receptor 1 (RyR1) may be one of the potentially critical pharmacological targets for studying the anxiolytic activity of NSMPs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::261cede05bc212866fe54351ac661638
https://doi.org/10.1021/acsomega.1c04468

Cytotoxic Activity and Composition of Petroleum Ether Extract from Magydaris tomentosa (Desf.) W. D. J. Koch (Apiaceae)

Autor: Giuseppina Autore, Stefania Marzocco, Carmen Formisano, Maurizio Bruno, Sergio Rosselli, Mariem Ben Jemia, Felice Senatore

Publikováno v: Molecules, Vol 20, Iss 1, Pp 1571-1578 (2015)

The petroleum ether extract of Magydaris tomentosa flowers (Desf.) W. D. J. Koch has been analyzed by GC-MS. It is mainly constituted by furanocoumarins such as xanthotoxin, xanthotoxol, isopimpinellin, and bergaptene. Other coumarins such as 7-metho

Externí odkaz: https://doaj.org/article/e403640350444050a8b7412476b6c2e8

Gut Metabolism of Furanocoumarins: Proposed Function of Co O-Methyltransferase

Autor: Bekir Engin Eser, Steven Ryan Susanto Tan, Jaehong Han

Publikováno v: ACS Omega
Tan, S R S, Eser, B E & Han, J 2020, ' Gut Metabolism of Furanocoumarins : Proposed Function of Co O-Methyltransferase ', ACS Omega, vol. 5, no. 47, pp. 30696-30703 . https://doi.org/10.1021/acsomega.0c04879
ACS Omega, Vol 5, Iss 47, Pp 30696-30703 (2020)

Gut metabolism of natural products is of great interest due to the altered biological activity of the metabolites. To study the gut metabolism of the dietary furanocoumarins, the biotransformation of Angelica dahurica was studied with human gut micro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94d8d56471896e589f445c0c179861a
https://doi.org/10.1021/acsomega.0c04879

Effect of co‐administration of Acori Tatarinowii Rhizoma volatile oil on pharmacokinetic fate of xanthotoxol, oxypeucedanin hydrate, and byakangelicin from Angelicae Dahuricae Radix in rat

Autor: Qian Zhang, Pu Jia, Jianghong Liu, Shixiang Wang, Xiaohui Zheng, Baimei Shi, Liujiao Bian

Publikováno v: Journal of Separation Science. 43:2349-2362

A combination of Angelicae Dahuricae Radix and Acori Tatarinowii Rhizoma has been widely used as the herb pair in traditional Chinese medicine to treat stroke, migraine, and epilepsy. However, the underlying synergistic mechanism of the herb pair rem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541ace600d393d2c06798bcb6bfaddce
https://doi.org/10.1002/jssc.201901250