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of 1 456
pro vyhledávání: '"xanthine oxidase inhibitor"'
Autor:
Juan Rong, Chenxia Han, Yan Huang, Yiqin Wang, Qi Qiu, Manjiangcuo Wang, Shisheng Wang, Rui Wang, Juqin Yang, Xia Li, Chenggong Hu, Zhiyao Chen, Lihui Deng, Wei Huang, Qing Xia, Dan Du
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 8, Pp 3591-3604 (2024)
Acute pancreatitis (AP) is a potentially fatal condition with no targeted treatment options. Although inhibiting xanthine oxidase (XO) in the treatment of AP has been studied in several experimental models and clinical trials, whether XO is a target
Externí odkaz:
https://doaj.org/article/106b7c1df2ac42c5b261a06291150944
Publikováno v:
Journal of Pharmacy & Pharmacognosy Research, Vol 11, Iss 3, Pp 401-413 (2023)
Context: The Sida genus, part of the Malvaceae family, is commonly used in traditional medicine due to its many beneficial properties, such as antigout, anti-rheumatic, anti-inflammatory, antitumor, and hepatoprotective effects. Various species of Si
Externí odkaz:
https://doaj.org/article/cd7b043720ee4fed9ce28aa7f56e0754
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The target of the study is to predict the inhibitory effect of amide derivatives on xanthine oxidase (XO) by building several models, which are based on the theory of the quantitative structure–activity relationship (QSAR). The heuristic method (HM
Externí odkaz:
https://doaj.org/article/399677b62a474eff979b8c4d2cb47bd2
Publikováno v:
Biomedicines, Vol 11, Iss 11, p 3074 (2023)
Metabolic dysfunction-associated steatotic liver disease (MASLD) includes patients with hepatic steatosis and at least one of five cardiometabolic risk factors. Xanthine oxidase (XO) represents a treatment target for MASLD. We aimed to evaluate the e
Externí odkaz:
https://doaj.org/article/743ddd79778d4b558f768bff56ffa6fd
Autor:
Hui Wang, Hongwei Zhang, Xiaomei Zhang, Yichen Yin, Guiquan Ding, Xiaowen Tang, Pengyi Hou, Shiwei Sun, Wei Wang
Publikováno v:
Journal of Functional Foods, Vol 100, Iss , Pp 105378- (2023)
Xanthine oxidase (XO) has been well-recognized as a key enzyme in the pathogenesis of hyperuricemia. In this study, Chuanxiong Rhizome, a tonic food widely consumed in China, was found to inhibit XO activity. The potential XO inhibitory ingredients w
Externí odkaz:
https://doaj.org/article/c7378ff42b5947eb91f8ebafeb14d2d2
Autor:
Tianshu Gao, Jin Xu, Yuxiao Xiao, Jiaqi Li, Weifeng Hu, Xiaoyu Su, Xudong Shen, Wan Yu, Zhen Chen, Baosheng Huang, Honglei Li, Xing Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Objective: To observe the antioxidative effects of N-(9,10-anthraquinone-2-ylcarbonyl) xanthine oxidase inhibitors (NAY) in vitro and in vivo models of hyperuricemia and explore the mechanism.Methods: A classical experimental method of acute toxicity
Externí odkaz:
https://doaj.org/article/ab9c85c30b1043669179e45c65f54950
Akademický článek
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Akademický článek
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Publikováno v:
Molecules, Vol 28, Iss 13, p 5141 (2023)
To explore the anti-hyperuricemia components in sunflower (Helianthus annuus L.) calathide extract (SCE), we identified abietic acid (AA) via liquid chromatography–mass spectrometry and found an excellent inhibitor of xanthine oxidase (IC50 = 10.60
Externí odkaz:
https://doaj.org/article/a2dfc43d3f204ced81e80207b8a6b555
Autor:
Tatsuya Maruhashi, Yukihito Higashi, Hisako Yoshida, Atsushi Tanaka, Kazuo Eguchi, Hirofumi Tomiyama, Kazuomi Kario, Toru Kato, Nozomu Oda, Nobuhiro Tahara, Mitsutoshi Oguri, Hirotaka Watada, Koichi Node
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
BackgroundXanthine oxidase is involved in the production of uric acid and the generation of superoxide anion. We evaluated the long-term effect of febuxostat, a non-purine selective xanthine oxidase inhibitor, on endothelial function in patients with
Externí odkaz:
https://doaj.org/article/5c4cd3f06f6c47798ecee9c3619ead53