Zobrazeno 1 - 10
of 334
pro vyhledávání: '"wim ceelen"'
Autor:
Stephanie Vermeulen, Sam Ernst, Eva Blondeel, Zihan Xia, Pekka Rappu, Jyrki Heino, Sándor Dedeyne, Hannelore Denys, Gwen Sys, Stefanie Gijsels, Herman Depypere, Philippe Tummers, Wim Ceelen, Ligia Craciun, Pieter Demetter, Olivier Raes, An Hendrix, Johan Van der Eycken, Olivier De Wever
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Taxanes, such as paclitaxel (PTX), stabilize microtubules and are used as a first-line therapy in multiple cancer types. Disruption of microtubule equilibrium, which plays an essential role in mitosis and cell homeostasis, ultimately results
Externí odkaz:
https://doaj.org/article/45ac459d71fb40c5a53b49a155765449
Autor:
Elly De Vlieghere, Koen Van de Vijver, Eva Blondeel, Nathan Carpentier, Rouba Ghobeira, Jarne Pauwels, Sebastian Riemann, Manon Minsart, Charlotte Fieuws, Johanna Mestach, Ans Baeyens, Nathalie De Geyter, Charlotte Debbaut, Hannelore Denys, Benedicte Descamps, Kathleen Claes, Anne Vral, Jo Van Dorpe, Kris Gevaert, Bruno G. De Geest, Wim Ceelen, Sandra Van Vlierberghe, Olivier De Wever
Publikováno v:
Biomaterials Research, Vol 27, Iss 1, Pp 1-18 (2023)
Abstract Background Long-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include three-dimensional (3D) cellular systems that take into account tumor microenvironment (TME) cell t
Externí odkaz:
https://doaj.org/article/3e5a307685aa4c44b056bfedd46942cf
Autor:
Panayiotis Tanos, Andrew D. Ablett, Ben Carter, Wim Ceelen, Lyndsay Pearce, Michael Stechman, Kathryn McCarthy, Jonathan Hewitt, Phyo Kyaw Myint
Publikováno v:
Asian Journal of Surgery, Vol 46, Iss 7, Pp 2668-2674 (2023)
Purpose: Post-operative complications following emergency abdominal surgery are associated with significant morbidity and mortality. Despite the knowledge of prognostic factors associated with poor surgical outcomes; few have described risks of poor
Externí odkaz:
https://doaj.org/article/910244e7995647a280a4f15f981e2daf
Publikováno v:
Bioengineering & Translational Medicine, Vol 9, Iss 2, Pp n/a-n/a (2024)
Abstract Background Elevated tumor tissue interstitial fluid pressure (IFP) is an adverse biomechanical biomarker that predicts poor therapy response and an aggressive phenotype. Advances in functional imaging have opened the prospect of measuring IF
Externí odkaz:
https://doaj.org/article/3efabbc69dec4754a8472bcaa6ec7bd3
Autor:
Amaniel Kefleyesus, Aditi Bhatt, Cecilia Escayola, Vladimir Khomyakov, Martin Hübner, Marc A. Reymond, René Thieme, Olivia Sgarbura, Wouter Willaert, Wim Ceelen, Andrea Di Giorgio, Giuseppe Vizzielli, Olivier Glehen, Manuela Robella, Naoual Bakrin
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionOvarian cancer (OC) is the primary cause of mortality in women diagnosed with gynecological cancer. Our study assessed pressurized intraperitoneal aerosol chemotherapy (PIPAC) as treatment for peritoneal surface metastases (PSM) from recu
Externí odkaz:
https://doaj.org/article/ee899b4025db472199d19dbeaa218c70
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/39fc90b22edf422d80cb1a58c75d2c67
Autor:
Mohammad Rahimi-Gorji, Charlotte Debbaut, Ghader Ghorbaniasl, Sarah Cosyns, Wouter Willaert, Wim Ceelen
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Intraperitoneal (IP) aerosolized anticancer drug delivery was recently introduced in the treatment of patients with peritoneal metastases. However, little is known on the effect of treatment parameters on the spatial distribution of the aero
Externí odkaz:
https://doaj.org/article/18283cef19234f249b083dd57206f399
Autor:
Wim Ceelen, Louis Sandra, Leen Van de Sande, Martin Graversen, Michael Bau Mortensen, An Vermeulen, Elke Gasthuys, Dries Reynders, Sarah Cosyns, Anne Hoorens, Wouter Willaert
Publikováno v:
EBioMedicine, Vol 82, Iss , Pp 104151- (2022)
Summary: Background: Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a novel method to treat patients with peritoneal metastases (PM). We aimed to study the tolerability, safety, pharmacokinetics, and tumour response of nanoparticle a
Externí odkaz:
https://doaj.org/article/26d9c8fadf15413aa59ef876540af857
Autor:
Elien De Thaye, Koen Van de Vijver, Joni Van der Meulen, Joachim Taminau, Glenn Wagemans, Hannelore Denys, Jo Van Dorpe, Geert Berx, Wim Ceelen, Jan Van Bocxlaer, Olivier De Wever
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Peritoneal spread indicates poor prognosis in patients with serous ovarian carcinoma (SOC) and is generally treated by surgical cytoreduction and chemotherapy. Novel treatment options are urgently needed to improve patient outcome. Clinicall
Externí odkaz:
https://doaj.org/article/06dcae893d8f4e05a6164052d60339cc
Publikováno v:
Drug Delivery, Vol 27, Iss 1, Pp 40-53 (2020)
Albumin is a remarkable carrier protein with multiple cellular receptor and ligand binding sites, which are able to bind and transport numerous endogenous and exogenous compounds. The development of albumin-bound drugs is gaining increased importance
Externí odkaz:
https://doaj.org/article/d89981ff248e4361bdb22cc44c94c0b6