Zobrazeno 1 - 10
of 506
pro vyhledávání: '"whole-cell vaccine"'
Publikováno v:
eLife, Vol 13 (2024)
Despite current antifungal therapy, invasive candidiasis causes >40% mortality in immunocompromised individuals. Therefore, developing an antifungal vaccine is a priority. Here, we could for the first time successfully attenuate the virulence of Cand
Externí odkaz:
https://doaj.org/article/1ff0dacc6043431aa5c4e020bcde8d6e
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Vaccination is an effective measure to prevent infection by pathogens. Live vaccines have higher protective efficacy than inactivated vaccines. However, how live vaccines interact with the host from a metabolic perspective is unknown. The present stu
Externí odkaz:
https://doaj.org/article/19839987860545ada9ea7281e0a02366
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Acinetobacter baumannii (A. baumannii) is a Gram-negative opportunistic pathogen widely attached to the surface of medical instruments, making it one of the most common pathogens of nosocomial infection, and often leading to cross-infection and co-in
Externí odkaz:
https://doaj.org/article/2cd64d38c22643dd9f5f5e238e722be5
Autor:
Shannon C. David, Erin B. Brazel, Eve V. Singleton, Vikrant Minhas, Zoe Laan, Catherine Scougall, Austen Y. Chen, Hui Wang, Chloe J. Gates, Kimberley T. McLean, Jeremy S. Brown, Giuseppe Ercoli, Rachel A. Higgins, Paul V. Licciardi, Kim Mulholland, Justin B. Davies, Timothy R. Hirst, James C. Paton, Mohammed Alsharifi
Publikováno v:
mBio, Vol 13, Iss 5 (2022)
ABSTRACT Streptococcus pneumoniae (Spn) remains a major cause of global mortality, with extensive antigenic diversity between capsular serotypes that poses an ongoing challenge for vaccine development. Widespread use of pneumococcal conjugate vaccine
Externí odkaz:
https://doaj.org/article/511cd819d0a5443389dd8f6cbe5374df
Autor:
Satya Ranjan Sahu, Swagata Bose, Manish Singh, Premlata Kumari, Abinash Dutta, Bhabasha Gyanadeep Utkalaja, Shraddheya Kumar Patel, Narottam Acharya
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
Candidiasis is a mycosis caused by opportunistic Candida species. The occurrence of fungal infections has considerably increased in the last few years primarily due to an increase in the number of immune-suppressed individuals. Alarming bloodstream i
Externí odkaz:
https://doaj.org/article/3238cda19b4d4db5aeb3da941c744618
Autor:
Gábor J. Szebeni, Róbert Alföldi, Lajos I. Nagy, Patrícia Neuperger, Nikolett Gémes, József Á. Balog, László Tiszlavicz, László G. Puskás
Publikováno v:
Vaccines, Vol 11, Iss 7, p 1254 (2023)
The advent of immunotherapy has revolutionized cancer treatments. However, the application of immune checkpoint inhibitors may entail severe side effects, with the risk of therapeutic resistance. The generation of chimeric antigen receptor (CAR) T-ce
Externí odkaz:
https://doaj.org/article/f75a057661764112b2285f31223e7e2d
Autor:
Gaelle Noel, Masoumeh Nakhost Lotfi, Sajedeh Mirshahvalad, Sedaghatpour Mahdi, David Tavel, Seyed M. Zahraei, Roxana Mansour Ghanaie, Tahereh Heidary, Aliahmad Goudarzi, Azardokht Kazemi, Abdollah Karimi, Alireza Nateghian, Mohand Ait-Ahmed, Nicole Guiso, Fereshteh Shahcheraghi, Fabien Taieb
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background Pertussis remain a global health concern, especially in infants too young to initiate their vaccination. Effective vaccination and high coverage limit the circulation of the pathogen, yet duration of protection is limited and boos
Externí odkaz:
https://doaj.org/article/526037339850413a89195ef0cf087c8f
Autor:
Gaelle Noel, Laurence Borand, Chanthy Leng, Chanthy Keang, Chhunly Botr, Bunnet Dim, Alexandra Kerleguer, Yik S. Peng, Navin Sreng, Vichit Ork, Mohand Ait-Ahmed, Nicole Guiso, Fabien Taieb
Publikováno v:
International Journal of Infectious Diseases, Vol 106, Iss , Pp 134-139 (2021)
Background: The Cambodia pertussis immunization schedule includes three doses given at age 6, 10 and 14 weeks using a whole-pertussis vaccine. No booster doses are included. Pertussis biological diagnosis is unavailable in Cambodia and its burden rem
Externí odkaz:
https://doaj.org/article/9535c16423ed41488b0ec42dc3506556
Autor:
Túllio T. Deusdará, Mellanie K. C. Félix, Helio de S. Brito, Edson W. S. Cangussu, Wellington de S. Moura, Benedito Albuquerque, Marcos G. Silva, Gil R. dos Santos, Paula B. de Morais, Elizangela F. da Silva, Yury O. Chaves, Luis Andre M. Mariúba, Paulo A. Nogueira, Spartaco Astolfi-Filho, Enedina N. Assunção, Sabrina Epiphanio, Claudio R. F. Marinho, Igor V. Brandi, Kelvinson F. Viana, Eugenio E. Oliveira, Alex Sander R. Cangussu
Publikováno v:
Vaccines, Vol 11, Iss 3, p 669 (2023)
Acinetobacter baumannii is a Gram-negative, immobile, aerobic nosocomial opportunistic coccobacillus that causes pneumonia, septicemia, and urinary tract infections in immunosuppressed patients. There are no commercially available alternative antimic
Externí odkaz:
https://doaj.org/article/fcd180b79cc64ee1beb6023939852fe4
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-12 (2020)
Abstract Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM. Systemic delivery of chemotherapeutic drugs is hampered by the diffi
Externí odkaz:
https://doaj.org/article/e4f593c5b8ca472a917d31612d151de2