Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex

Autor: Lin Lin, Yingdong Shi, Mengli Wang, Chao Wang, Qing Lu, Jinwei Zhu, Rongguang Zhang

Publikováno v: Cell Reports, Vol 34, Iss 8, Pp 108770- (2021)

Summary: Stereocilia, the mechanosensory organelles on the apical surface of hair cells, are necessary to detect sound and carry out mechano-electrical transduction. An electron-dense matrix is located at the distal tips of stereocilia and plays cruc

Externí odkaz: https://doaj.org/article/b51a49c78912403f866d6a4f24658f22

Folding and Misfolding of a PDZ Tandem Repeat

Autor: Stefano Gianni, Lorenzo Visconti, Livia Pagano, Francesca Troilo, Francesca Malagrinò, Angelo Toto

Publikováno v: Journal of molecular biology. 433(7)

Although the vast majority of the human proteome is represented by multi-domain proteins, the study of multi-domain folding and misfolding is a relatively poorly explored field. The protein Whirlin is a multi-domain scaffolding protein expressed in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59d1991bdd577866db96cf59504f33eb
https://pubmed.ncbi.nlm.nih.gov/33539879

Structural plasticity of the HHD 2 domain of whirlin

Autor: Florence Cordier, Nicolas Wolff, Ahmed Haouz, Lucas Chataigner, Florent Delhommel, Frederick Saul

Publikováno v: FEBS Journal
FEBS Journal, Wiley, 2018, 285 (20), pp.3738-3752. ⟨10.1111/febs.14614⟩
FEBS Journal, 2018, 285 (20), pp.3738-3752. ⟨10.1111/febs.14614⟩

International audience; Whirlin is a protein essential to sensory neurons. Its defects are responsible for nonsyndromic deafness or for the Usher syndrome, a condition associating congenital deafness and progressive blindness. This large multidomain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb05bb0cd7da7464fbfcb1ae88e820b
https://doi.org/10.1111/febs.14614

Identification of whirlin domains interacting with espin: A study of the mechanism of Usher syndrome type II

Autor: Yuchen Wang, Le Wang, Jilong Hao, Xianhui Gong, Bo Wei, Xueqi Fu, Shu Xing, Junfeng Ma, Yuan Sui

Publikováno v: Molecular Medicine Reports

Usher syndrome is the most common condition of combined blindness and deafness and is classified into three types (USH1‑USH3). USH2 is the most commonly diagnosed of all Usher syndrome cases. There are three identified proteins (usherin, GPR98 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b597b4389441ab9ad0fba1980063471
https://pubmed.ncbi.nlm.nih.gov/31638198

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