Zobrazeno 1 - 10
of 20
pro vyhledávání: '"wayne kong"'
Autor:
Siobhan K. McRee, Chelsea Chen, Christophe Colas, Wie Fang, Wayne Kong, Fang Liu, Jason Long, Jared Moore, Alex Pankov, Dan Shore, Joanne Tan, Robert Warne, Rakesh Vekariya, Amy Young, Anneleen Daemen, Anthony Romero, Melissa R. Junttila, Lori S. Friedman, Kyle A. Edgar
Publikováno v:
Cancer Research. 83:4998-4998
Amplification and copy number gains of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis (Ganesan et al 2012; Takita et al. 2017). A synthetic lethal interaction of PLK4 wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453598ec189a9b61952b0e915dec5da3
https://doi.org/10.1158/1538-7445.am2023-4998
https://doi.org/10.1158/1538-7445.am2023-4998
Autor:
Xi Chen, John Eksterowicz, Jessica Sun, Tatiana Zavorotinskaya, Valeria R. Fantin, Xuelei Yan, Wayne Kong, Dena Sutimantanapi, Yosup Rew, Xiaohui Du, Haiying Zhou, Liusheng Zhu, Daqing Sun, Tom Huang, Qiuping Ye, Julio C. Medina, Nadine Jahchan
Publikováno v:
Journal of Medicinal Chemistry. 62:6751-6764
Structure-based modification of mifepristone (1) led to the discovery of novel mifepristone derivatives with improved selectivity profile. Addition of a methyl group at the C10 position of the steroid has a significant impact on progesterone receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f205ab8f3951dd5ee98d5cf9ed9d46
https://doi.org/10.1021/acs.jmedchem.9b00711
https://doi.org/10.1021/acs.jmedchem.9b00711
Autor:
Kyle A. Edgar, Amy Young, Jared Moore, Xi Chen, Wei Fang, Jae H. Chang, Wayne Kong, Jason E. Long, Aleksandr Pankov, Anneleen Daemen, Daniel G. Shore, Robert Warne, Paul Gibbons, Chudi O. Ndubaku, Melissa R. Junttila, Lori S. Friedman
Publikováno v:
Cancer Research. 82:2633-2633
Amplification and copy number alterations of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis. Recent work identified a key vulnerability associated with amplicon-driven o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaffc3f878f0559ccf8420f27e6889ca
https://doi.org/10.1158/1538-7445.am2022-2633
https://doi.org/10.1158/1538-7445.am2022-2633
Autor:
Dena Sutimantanapi, Yosup Rew, Xiaohui Du, Lori Friedman, Tatiana Zavorotinskaya, Jessica Sun, Haiying Zhou, Hiroyuki Kawai, John Eksterowicz, Tom Huang, Daqing Sun, Qiuping Ye, Johnny Pham, wayne kong, Jared Moore, kejia wu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::124c3c08411db884fec082d1e252cbab
https://doi.org/10.1021/scimeetings.0c06729
https://doi.org/10.1021/scimeetings.0c06729
Autor:
Tatiana Zavorotinskaya, Natalie Yuen, Xi Chen, Daqing Sun, Dena Sutimantanapi, Jessica Sun, Todd C. Metzger, Jae H. Chang, Yuping Chen, John Eksterowicz, Valeria Fantin, Wayne Kong, Brenda Chan, Jared Moore, Xiaohui Du, Qiuping Ye, Chudi Ndubaku, Tom Huang, Lori Friedman, Melissa R. Junttila, Frank Duong, Brian R Blank
Publikováno v:
Journal of medicinal chemistry. 63(18)
The adenosinergic pathway represents an attractive new therapeutic approach in cancer immunotherapy. In this pathway, ecto-5-nucleotidase CD73 has the unique function of regulating production of immunosuppressive adenosine (ADO) through the hydrolysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06063be680b50d6de82ea33c0efe9b6
https://pubmed.ncbi.nlm.nih.gov/32865411
https://pubmed.ncbi.nlm.nih.gov/32865411
Autor:
Hiro Kawai, Jared Moore, Wayne Kong, Jessica Sun, Brian R Blank, Xiaohui Du, Johnny Pham, Melissa R. Junttila, Yosup Rew, Kejia Wu, Brenda Chan, Yuping Chen, Lori Friedman, Chien-Hung Yeh, Daqing Sun, Todd C. Metzger, Tatiana Zavorotinskaya, Frank Duong, Natalie Yuen, Chelsea Chen, Dena Sutimantanapi
Publikováno v:
Cancer Research. 80:LB-115
The 5' ecto-nucleotidase CD73 is dynamically expressed in distinct biological contexts as a means to increase the adenosine metabolite, which functions to limit immune activation and prevent excessive inflammation. CD73 activity is required for the f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d382d1b7e4983c04a5c18ff8655e4f9
https://doi.org/10.1158/1538-7445.am2020-lb-115
https://doi.org/10.1158/1538-7445.am2020-lb-115
Autor:
Yuping Chen, Wayne Kong, Xiaohui Du, Jared Moore, Dena Sutimantanapi, Jessica Sun, Melissa R. Junttila, Xi Chen, Natalie Yuen, Todd C. Metzger, Lori Friedman, Daqing Sun, Tom Huang, Frank Duong, Tatiana Zavorotinskaya, Brian R Blank, Brenda Chan
Publikováno v:
Cancer Research. 80:1037-1037
CD73 has emerged as an attractive target for cancer immunotherapy. CD73 (ecto-5-nucleotidase) is a glycosyl phosphatidyl inositol (GPI)-anchored cell surface protein and catalyzes the hydrolysis of AMP into immunosuppressive adenosine and inorganic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1356fc4ed2cd9c90edec00fbf5cf6da7
https://doi.org/10.1158/1538-7445.am2020-1037
https://doi.org/10.1158/1538-7445.am2020-1037
Autor:
Melissa R. Junttila, Aleksandr Pankov, Lori Friedman, Frank Duong, Omar Kabbarah, Haiying Zhou, Wayne Kong, Shravani Barkund, Jessica Sun, Natalie Yuen, Anneleen Daemen, Dan McWeeney, Qiuping Ye
Publikováno v:
Cancer Research. 80:4123-4123
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal cancers, with a 5-year survival rate of 8%. Chemotherapy remains the main treatment option for patients with advanced and metastatic tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f16d77abad92c157df9ae047bbf60478
https://doi.org/10.1158/1538-7445.am2020-4123
https://doi.org/10.1158/1538-7445.am2020-4123
Autor:
Yuping Chen, Melissa R. Junttila, Natalie Yuen, Jared Moore, Dena Sutimantanapi, Tatiana Zavorotinskaya, Daqing Sun, Todd C. Metzger, Brian R Blank, Wayne Kong, Lori Friedman, Tom Huang, Jessica Sun, Xiaohui Du, Chelsea Chen, Brenda Chan, Frank Duong
Publikováno v:
Cancer Research. 80:1023-1023
Adenosine has emerged as a key immunosuppressive metabolite within the tumor microenvironment (TME). A persistently elevated concentration of adenosine in TME can impair immune control of tumor growth by diminishing cytotoxic T-cell responses and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60fd2e45991efe1456a8ff7419cba96d
https://doi.org/10.1158/1538-7445.am2020-1023
https://doi.org/10.1158/1538-7445.am2020-1023
Autor:
Lori Friedman, Shravani Barkund, Ganapati Hegde, Jessica Sun, Wayne Kong, Haiying Zhou, Aleksandr Pankov, Padmini Narayanan, Omar Kabbarah, Anneleen Daemen
Publikováno v:
Cancer Research. 80:4121-4121
Preclinical studies have shown that GR activation leads to decreased response to antimetabolites, taxanes, and platinum agents, while GR inhibition enhances therapeutic efficacy. The novel, selective GR antagonist ORIC-101 is under clinical evaluatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::449fdb34c739a883c6d240ab88551f93
https://doi.org/10.1158/1538-7445.am2020-4121
https://doi.org/10.1158/1538-7445.am2020-4121