Zobrazeno 1 - 10
of 353
pro vyhledávání: '"vrac"'
Autor:
Eric E. Figueroa, Jerod S. Denton
Publikováno v:
Channels, Vol 16, Iss 1, Pp 27-36 (2022)
Newly emerging roles of LRRC8 volume-regulated anion channels (VRAC) raise important questions about the therapeutic potential of VRAC in the treatment of epilepsy, type 2 diabetes, and other human diseases. A critical barrier to evaluating whether V
Externí odkaz:
https://doaj.org/article/1309af476b9141f4a355509a3ed9d3ba
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Objective: In this study, we utilized bibliometric methods to assess the worldwide scientific output and identify hotspots related to the research on the volume-regulated anion channel (VRAC) from 2014 to 2022.Methods: From Web of Science, we obtaine
Externí odkaz:
https://doaj.org/article/f205ef73966d4960adbf825eb887f877
Publikováno v:
Pharmacology Research & Perspectives, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Syringin is a natural chemical compound first isolated from the bark of lilac and is known to have neuroprotective effects in middle cerebral artery occlusion (MCAO). Volume regulated anion channel (VRAC) is a cell swelling‐activated anion
Externí odkaz:
https://doaj.org/article/4d1d9488e65d459c9f5b52db3547f5ce
Autor:
Haifeng Zhang, Zhenghui Jing, Rong Liu, Yassin Shada, Sindhwani Shria, Shiyu Cui, Yuhua Ren, Yuan Wei, Liangming Li, Shuang Peng
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e16872- (2023)
Leucine-rich repeat-containing 8 A (LRRC8A) is an essential component of the volume-regulated anion channel (VRAC), which plays a vital role in cell proliferation, migration, apoptosis, and drug resistance. In this study, we investigated the effects
Externí odkaz:
https://doaj.org/article/71864931a26b4a26adb200a2acec107d
Publikováno v:
eLife, Vol 12 (2023)
Volume-regulated anion channels (VRACs) mediate volume regulatory Cl- and organic solute efflux from vertebrate cells. VRACs are heteromeric assemblies of LRRC8A-E proteins with unknown stoichiometries. Homomeric LRRC8A and LRRC8D channels have a sma
Externí odkaz:
https://doaj.org/article/aa7ea42837e04d9ba238be46ae7f3f71
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Volume Regulated Anion Channels (VRAC) are critical contributors to cell volume homeostasis and are expressed ubiquitously in all vertebrate cells. VRAC sense increases in cell volume, and act to return cells to baseline volume in a process known as
Externí odkaz:
https://doaj.org/article/b0d90a8427c74006805d6b4c13fcb950
Akademický článek
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Publikováno v:
Biology, Vol 12, Iss 7, p 1039 (2023)
Lymphatic vessels are capable of sustaining lymph formation and propulsion via an intrinsic mechanism based on the spontaneous contraction of the lymphatic muscle in the wall of lymphatic collectors. Exposure to a hyper- or hypo-osmolar environment c
Externí odkaz:
https://doaj.org/article/f7a8a673a1d44ca6bcaf0695940840bc
Autor:
Go Kasuya, Osamu Nureki
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Members of the leucine-rich repeat-containing 8 (LRRC8) protein family, composed of five LRRC8A-E isoforms, are pore-forming components of the volume-regulated anion channel (VRAC), which is activated by cell swelling and releases chloride ions (Cl
Externí odkaz:
https://doaj.org/article/94ae82521d374c6682ec5947dfa85190
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 3, Pp 176-181 (2020)
The volume-regulated anion channel (VRAC) plays a central role in maintaining cell volume in response to osmotic stress. Leucine-rich repeat-containing 8A (LRRC8A) was recently identified as an essential component of VRAC although other Cl− channel
Externí odkaz:
https://doaj.org/article/cde4fc99bc274060b139d6cdf87a47a1