Final results from the PERUSE study of first-line pertuzumab plus trastuzumab plus a taxane for HER2-positive locally recurrent or metastatic breast cancer, with a multivariable approach to guide prognostication

Autor: Bachelot, T., Bouzid, K., Campone, M., Desmoulins, I., Coudert, B., Bondarenko, I., Nowecki, Z., Glogowska, I., Ciruelos Gil, E., Errihani, H., Dalenc, F., Ricci, F., Dieras, V., Kaufman, B., Paluch-Shimon, S., Wardley, A., Schneeweiss, A., Ferreira, A., Mano, M., Kalofonos, H., Andreetta, C., Puglisi, F., Montemurro, F., Barrett, S., Zhang, Q., Mavroudis, D., Matus, J., Villarreal Garza, C., Beato, C., Ismael, G., Hu, X., Abdel Azeem, H., Gaafar, R., Perrin, C., Kerbrat, P., Ettl, J., Paepke, S., Hitre, E., Lang, I., Trudeau, M., Verma, S., Li, H., Hoffmann, O., Aktas, B., Cariello, A., Cruciani, G., Tienghi, A., Tondini, C., Al-Twegieri, T., Loman, N., Laing, R., Miles, D., Brain, E., Fasching, P., Lux, M., Frassoldati, A., Aziz, Z., Salas, J., Streb, J., Krzemieniecki, K., Wronski, A., Garcia Garcia, J., Menjon Beltran, S., Cicin, I., Schmid, P., Gallagher, C., Turner, N., Tong, Z., Boer, K., Juhász, B., Horvath, Z., Bianchini, G., Gianni, L., Curigliano, G., Juarez Ramiro, A., Susnjar, S., Matos, E., Sevillano, E., Garcia Estevez, L., Gokmen, E., Uslu, R., Wildiers, H., Schutz, F., Cruz, M., Bourgeois, H., von Schumann, R., Stemmer, S., Dominguez, A., Morales-Vásques, F., Wojtukiewicz, M., Trifunovic, J., Echarri Gonzalez, M.J., Illarramendi Mañas, J., Martinez De Dueñas, E., Voitko, N., Hicks, J., Waters, S., Barrett-Lee, P., Wheatley, D., De Boer, R., Cocquyt, V., Jerusalem, G., Barrios, C., Panasci, L., Mattson, J., Tanner, M., Gozy, M., Vasilopoulos, G., Papandreou, C., Revesz, J., Battelli, N., Benedetti, G., Latini, L., Gridelli, C., Lazaro Leon, J., Alarcón Company, J., Arance Fernandez, A., Barnadas Molins, A., Calvo Plaza, I., Bratos, R., Gonzalez Martin, A., Izarzugaza Peron, Y., Klint, L., Kovalev, A., McCarthy, N., Yeo, B., Kee, D., Thomson, J., White, S., Greil, R., Wang, S., Artignan, X., Juhasz-Böess, I., Rody, A., Ngan, R., Dourleshter, F., Goldberg, H., Doni, L., Di Costanzo, F., Ferraù, F., Drobniene, M., Aleknavicius, E., Rashid, K., Costa, L., de la Cruz Merino, L., Garcia Saenz, J., López, R., Del Val Munoz, O., Ozyilkan, O., Azribi, F., Jaafar, H., Baird, R., Verrill, M., Beith, J., Petzer, A., Moreira de Andrade, J., Bernstein, V., Macpherson, N., Rayson, D., Saad Eldin, I., Achille, M., Augereau, P., Müller, V., Rasco, A., Evron, E., Katz, D., Berardi, R., Cascinu, S., De Censi, A., Gennari, A., El-Saghir, N., Ghosn, M., Oosterkamp, H.M., Van den Bosch, J., Kukulska, M., Kalinka, E., Alonso, J., Dalmau Portulas, E., Del Mar Gordon Santiago, M., Pelaez Fernandez, I., Aksoy, S., Altundag, K., Senol Coskun, H., Bozcuk, H., Shparyk, Y., Barraclough, L., Levitt, N., Panwar, U., Kelly, S., Rigg, A., Varughese, M., Castillo, C., Fein, L., Malik, L., Stuart-Harris, R., Singer, C., Stoeger, H., Samonigg, H., Feng, J., Cedeño, M., Ruohola, J., Berdah, J.-F., Goncalves, A., Orfeuvre, H., Grischke, E.-M., Simon, E., Wagner, S., Koumakis, G., Papazisis, K., Ben Baruch, N., Fried, G., Geffen, D., Karminsky, N., Peretz, T., Cavanna, L., Pedrazzioli, P., Grasso, D., Ruggeri, E., D’Auria, G., Moscetti, L., Juozaityte, E., Rodriguez Cid, J., Roerdink, H., Siddiqi, N., Passos Coelho, J., Arcediano Del Amo, A., Garcia Garre, E., García Gonzalez, M., Garcia-Palomo Perez, A., Herenandez Perez, C., Lopez Alvarez, P., Lopez De Ceballos, M.H., Martínez Jañez, N., Mele Olive, M., McAdam, K., Perren, T., Dunn, G., Humphreys, A., Taylor, W., Vera, R., Kaen, L., Andel, J., Steger, G., De Grève, J., Huizing, M., Hegg, R., Joy, A., Kuruvilla, P., Sehdev, S., Smiljanic, S., Kütner, R., Alexandre, J., Grosjean, J., Laplaige, P., Largillier, R., Maes, P., Martin, P., Pottier, V., Christensen, B., Khandan, F., Lück, H.-J., Zahm, D.-M., Fountzilas, G., Karavasilis, V., Safra, T., Inbar, M., Ryvo, L., Bonetti, A., Seles, E., Giacobino, A., Chavarri Guerra, Y., de Jongh, F., van der Velden, A., van Warmerdam, L., Vrijaldenhoven, S., Smorenburg, C.H., Cavero, M., Andres Conejero, R., Oltra Ferrando, A., Redondo Sanchez, A., Ribelles Entrena, N., Saura Grau, S., Viñas Vilaro, G., Bachmeier, K., Beresford, M., Butt, M., Joffe, J., Poole, C., Woodings, P., Chakraborti, P., Yordi, G., Woodward, N., Nobre, A., Luiz Amorim, G., Califaretti, N., Fox, S., Robidoux, A., Li, E., Li, N., Jiang, J., Soria, T., Padrik, P., Lahdenpera, O., Barletta, H., Dohollou, N., Genet, D., Prulhiere, K., Coeffic, D., Facchini, T., Vieillot, S., Catala, S., Teixeira, L., Hesse, T., Kühn, T., Ober, A., Repp, R., Schröder, W., Pectasides, D., Bodoky, G., Kahan, Z., Jiveliouk, I., Rosengarten, O., Rossi, V., Alabiso, O., Pérez Martínez, M., van de Wouw, A.J., Smok-Kalwat, J., Damasecno, M., Augusto, I., Sousa, G., Saadein, A., Abdelhafiez, N., Abulkhair, O., Antón Torres, A., Corbellas Aparicio, M., Llorente Domenech, R., Florián Jerico, J., Garcia Mata, J., Gil Raga, M., Galan Brotons, A., Llombart Cussac, A., Llorca Ferrandiz, C., Martinez Del Prado, P., Olier Garate, C., Rodriguez Sanchez, C., Sanchez Gomez, R., Santisteban Eslava, M., Soberino, J., Vidal Losada Garcia, M., Soto de Prado, D., Torrego Garcia, J., Vicente Rubio, E., Garcia, M., Murias Rosales, A., Granstam Björneklett, H., Narbe, U., Jafri, M., Rea, D., Newby, J., Jones, A., Westwell, S., Ring, A., Alonso, I., Rodríguez, R., Ciruelos, E. ^{2, 3}, Peretz-Yablonski, T. ⁷, Merot, J.-L. ¹⁵, Trask, P. ¹⁶, du Toit, Y. ^{17, ¶}, Pena-Murillo, C. ¹⁷, Revelant, V. ¹⁸, Klingbiel, D. ¹⁹

Publikováno v: In Annals of Oncology October 2021 32(10):1245-1255

De-Escalated Neoadjuvant Trastuzumab-Emtansine With or Without Endocrine Therapy Versus Trastuzumab With Endocrine Therapy in HR+/HER2+ Early Breast Cancer: 5-Year Survival in the WSG-ADAPT-TP Trial.

Autor: Harbeck N; West German Study Group, Moenchengladbach, Germany.; Department of Gynecology and Obstetrics and CCCMunich, Breast Center, LMU University Hospital, Munich, Germany., Nitz UA; West German Study Group, Moenchengladbach, Germany.; Breast Center Niederrhein, Ev. Hospital Bethesda, Moenchengladbach, Germany., Christgen M; Institute of Pathology, Medical School Hannover, Hannover, Germany., Kümmel S; West German Study Group, Moenchengladbach, Germany.; Breast Unit, Kliniken Essen-Mitte, Essen, Germany.; Department of Gynecology with Breast Center, Charité-Universitätsmedizin Berlin, Berlin, Germany., Braun M; Breast Center, Rotkreuz Clinics Munich, Munich, Germany., Schumacher C; Breast Center, St Elisabeth Hospital Cologne, Cologne, Germany., Potenberg J; Ev. Waldkrankenhaus Berlin, Berlin, Germany., Tio J; Department of Gynecology, University Hospital Münster, Münster, Germany., Aktas B; Women's Clinic, University Clinics Essen, Essen, Germany.; University Clinics Leipzig, Women's Clinic, Leipzig, Germany., Forstbauer H; Oncology Practice Network Troisdorf, Troisdorf, Germany., Grischke EM; Women's Clinic, University Clinics Tuebingen, Tuebingen, Germany., Scheffen I; West German Study Group, Moenchengladbach, Germany.; Breast Center Niederrhein, Ev. Hospital Bethesda, Moenchengladbach, Germany., Malter W; Department of Obstetrics and Gynecology, Breast Center, University Hospital, Cologne, Germany., von Schumann R; Breast Center Niederrhein, Ev. Hospital Bethesda, Moenchengladbach, Germany., Just M; Oncological Practice, Bielefeld, Germany., Zu Eulenburg C; West German Study Group, Moenchengladbach, Germany.; Department of Medical Biometry and Epidemiology, University Medical Center Hamburg, Hamburg, Germany., Biehl C; Westphalian Brest Center Dortmund, Dortmund, Germany., Kolberg-Liedtke C; Department of Gynecology with Breast Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Women's Clinic, University Clinics Essen, Essen, Germany., Deurloo R; F. Hoffmann-La Roche Ltd, Basel, Switzerland., de Haas S; F. Hoffmann-La Roche Ltd, Basel, Switzerland., Jóźwiak K; Institute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany., Hauptmann M; Institute of Biostatistics and Registry Research, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany., Kates R; West German Study Group, Moenchengladbach, Germany., Graeser M; West German Study Group, Moenchengladbach, Germany.; Breast Center Niederrhein, Ev. Hospital Bethesda, Moenchengladbach, Germany.; Department of Gynecology, University Medical Center Hamburg, Hamburg, Germany., Wuerstlein R; West German Study Group, Moenchengladbach, Germany.; Department of Gynecology and Obstetrics and CCCMunich, Breast Center, LMU University Hospital, Munich, Germany., Kreipe HH; Institute of Pathology, Medical School Hannover, Hannover, Germany., Gluz O; West German Study Group, Moenchengladbach, Germany.; Breast Center Niederrhein, Ev. Hospital Bethesda, Moenchengladbach, Germany.; University Clinics Cologne, Cologne, Germany.

Publikováno v: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Aug 01; Vol. 41 (22), pp. 3796-3804. Date of Electronic Publication: 2023 Feb 21.

The use of breast ultrasound for prediction of pathologic complete response in different subtypes of early breast cancer within the WSG-ADAPT subtrials.

Autor: Graeser M; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Breast Center Niederrhein, Ev. Hospital Bethesda, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Department of Gynecology, University Medical Center Hamburg, Martinistrasse 52, 20251, Hamburg, Germany. Electronic address: monika.graeser@wsg-online.com., Harbeck N; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Breast Center, Department of Gynecology and Obstetrics and CCCLMU, LMU University Hospital, Marchioninistrasse 15, 81377, Munich, Germany., Gluz O; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Breast Center Niederrhein, Ev. Hospital Bethesda, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; University Hospital Cologne, Kerpener Strasse 62, 50937, Cologne, Germany., Würstlein R; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Breast Center, Department of Gynecology and Obstetrics and CCCLMU, LMU University Hospital, Marchioninistrasse 15, 81377, Munich, Germany., Zu Eulenburg C; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany., Schumacher C; Breast Center, St. Elisabeth Hospital, Werthmannstrasse 1, 50935, Cologne, Germany., Grischke EM; Women's Clinic, University Clinics Tuebingen, Calwerstrasse 7, 72076, Tuebingen, Germany., Forstbauer H; Practice Network Troisdorf, Schlossstrasse 18, 53840, Troisdorf, Germany., Dimpfl M; Breast Center, Department of Gynecology and Obstetrics and CCCLMU, LMU University Hospital, Marchioninistrasse 15, 81377, Munich, Germany., Braun M; Breast Center, Rotkreuz Clinics Munich, Nymphenburger Strasse 163, 80634, Munich, Germany., Christgen M; Institute of Pathology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany., Kreipe HH; Institute of Pathology, Medical School Hannover, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany., Potenberg J; Ev. Waldkrankenhaus Berlin, Stadtrandstrasse 555, 13589, Berlin, Germany., von Schumann R; Breast Center Niederrhein, Ev. Hospital Bethesda, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany., Aktas B; Women's Clinic, University Clinics Essen, Hufelandstrasse 55, 45147, Essen, Germany; Women's Clinic, University Clinics Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany., Kolberg-Liedtke C; Women's Clinic, University Clinics Essen, Hufelandstrasse 55, 45147, Essen, Germany; University Hospital Charité, Humboldt University, Chariteplatz 1, 10117, Berlin, Germany., Kümmel S; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; University Hospital Charité, Humboldt University, Chariteplatz 1, 10117, Berlin, Germany; Breast Unit, Kliniken Essen-Mitte, Henricistrasse 92, 45136, Essen, Germany., Nitz U; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany; Breast Center Niederrhein, Ev. Hospital Bethesda, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.

Publikováno v: Breast (Edinburgh, Scotland) [Breast] 2021 Oct; Vol. 59, pp. 58-66. Date of Electronic Publication: 2021 Jun 14.

LBA14 De-escalated neoadjuvant T-DM1 with or without endocrine therapy (ET) vs trastuzumab+ET in early HR+/HER2+ breast cancer (BC): ADAPT-TP survival results

Autor: Harbeck, N. ¹, Nitz, U. ², Christgen, M. ³, Kuemmel, S. ⁴, Braun, M. ⁵, Schumacher, C. ⁶, Potenberg, J. ⁷, Tio, J. ⁸, Aktas, B. ⁹, Malter, W. ¹⁰, Forstbauer, H. ¹¹, von Schumann, R. ¹², Just, M. ¹³, Jóźwiak, K. ¹⁴, Hauptmann, M. ¹⁴, Kates, R. ¹⁵, Gräser, M. ¹⁶, Wuerstlein, R. ¹⁷, Kreipe, H. ³

Publikováno v: In Annals of Oncology September 2020 31 Supplement 4:S1146-S1146

Magnetic resonance imaging and ultrasound for prediction of residual tumor size in early breast cancer within the ADAPT subtrials.

Autor: Graeser M; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany. monika.graeser@wsg-online.com.; Ev. Hospital Bethesda, Breast Center Niederrhein, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany. monika.graeser@wsg-online.com.; Department of Gynecology, University Medical Center Hamburg, Martinistrasse 52, 20251, Hamburg, Germany. monika.graeser@wsg-online.com., Schrading S; Department of Diagnostic and Interventional Radiology, Hospital of the University of Aachen, RWTH, Pauwelsstrasse 30, 52074, Aachen, Germany., Gluz O; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; University Hospital Cologne, Kerpener Strasse 62, 50937, Cologne, Germany., Strobel K; Department of Diagnostic and Interventional Radiology, Hospital of the University of Aachen, RWTH, Pauwelsstrasse 30, 52074, Aachen, Germany., Herzog C; Radiology, Burgstrasse 7, 80331, Munich, Germany., Umutlu L; Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany., Frydrychowicz A; Department of Radiology and Nuclear Medicine, Schleswig-Holstein University Hospital, Campus Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany., Rjosk-Dendorfer D; Department of Radiology, University Hospital, LMU Munich, Marchioninistrasse. 15, 81377, Munich, Germany., Würstlein R; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; Department of Gynecology and Obstetrics, Breast Center, University of Munich (LMU) and CCCLMU, Marchioninistrasse 15, 81377, Munich, Germany., Culemann R; Medizinisches Versorgungszentrum Radiologie Rhein-Sieg, GFO Kliniken Troisdorf, Hospitalstrasse 45, 53840, Troisdorf, Germany., Eulenburg C; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany., Adams J; Alcedis GmbH, Winchesterstrasse 3, 35394, Giessen, Germany., Nitzsche H; Ev. Hospital Bethesda, Breast Center Niederrhein, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany., Prange A; Department of Radiology, Clinics Essen-Mitte, Breast Centre, Henricistrasse 92, 45136, Essen, Germany., Kümmel S; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; Clinics Essen-Mitte, Breast Centre, Henricistrasse 92, 45136, Essen, Germany.; University Hospital Charité, Women's Clinic, Berlin, Charitéplatz 1, 10117, Berlin, Germany., Grischke EM; University Clinic Tuebingen, Women's Clinic, Calwerstrasse 7, 72076, Tuebingen, Germany., Forstbauer H; Practice Network Troisdorf, Schlossstrasse 18, 53840, Troisdorf, Germany., Braun M; Red Cross Women's Hospital, Nymphenburger Strasse 163, 80634, Munich, Germany., Potenberg J; Ev. Waldkrankenhaus Berlin, Stadtrandstrasse 555, 13589, Berlin, Germany., von Schumann R; Ev. Hospital Bethesda, Breast Center Niederrhein, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany., Aktas B; Department of Gynecology and Obstetrics, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.; Department of Gynecology, University Hospital Leipzig, Liebeigstrasse 20A, 04103, Leipzig, Germany., Kolberg-Liedtke C; University Hospital Charité, Women's Clinic, Berlin, Charitéplatz 1, 10117, Berlin, Germany.; Department of Gynecology and Obstetrics, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany., Harbeck N; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; Department of Gynecology and Obstetrics, Breast Center, University of Munich (LMU) and CCCLMU, Marchioninistrasse 15, 81377, Munich, Germany., Kuhl CK; Department of Diagnostic and Interventional Radiology, Hospital of the University of Aachen, RWTH, Pauwelsstrasse 30, 52074, Aachen, Germany., Nitz U; West German Study Group, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.; Ev. Hospital Bethesda, Breast Center Niederrhein, Ludwig-Weber-Strasse 15, 41061, Moenchengladbach, Germany.

Publikováno v: Breast cancer research : BCR [Breast Cancer Res] 2021 Mar 18; Vol. 23 (1), pp. 36. Date of Electronic Publication: 2021 Mar 18.