The solution structure of Dead End bound to AU-rich RNA reveals an unusual mode of tandem RRM-RNA recognition required for mRNA regulation.

Autor: Duszczyk MM; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland. m.m.duszczyk@gmail.com., Wischnewski H; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland., Kazeeva T; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland., Arora R; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland., Loughlin FE; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland.; Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800, VIC, Australia., von Schroetter C; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland.; Institute of Biochemistry, Department of Biology, ETH Zürich, 8093, Zürich, Switzerland., Pradère U; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Hall J; Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093, Zürich, Switzerland., Ciaudo C; Institute of Molecular Health Sciences, ETH Zürich, 8093, Zürich, Switzerland. cciaudo@ethz.ch., Allain FH; Institute of Molecular Biology and Biophysics, ETH Zürich, 8093, Zürich, Switzerland. allain@bc.biol.ethz.ch.; Institute of Biochemistry, Department of Biology, ETH Zürich, 8093, Zürich, Switzerland. allain@bc.biol.ethz.ch.

Publikováno v: Nature communications [Nat Commun] 2022 Oct 06; Vol. 13 (1), pp. 5892. Date of Electronic Publication: 2022 Oct 06.

Recognition of N6-Methyladenosine by the YTHDC1 YTH Domain Studied by Molecular Dynamics and NMR Spectroscopy: The Role of Hydration.

Autor: Krepl M; Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65 Brno, Czech Republic., Damberger FF; Department of Biology, Institute of Biochemistry, ETH Zürich, 8093 Zürich, Switzerland., von Schroetter C; Department of Biology, Institute of Biochemistry, ETH Zürich, 8093 Zürich, Switzerland., Theler D; Department of Biology, Institute of Biochemistry, ETH Zürich, 8093 Zürich, Switzerland., Pokorná P; Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65 Brno, Czech Republic.; National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kamenice 5, 625 00 Brno, Czech Republic., Allain FH; Department of Biology, Institute of Biochemistry, ETH Zürich, 8093 Zürich, Switzerland., Šponer J; Institute of Biophysics of the Czech Academy of Sciences, Kralovopolska 135, 612 65 Brno, Czech Republic.; Regional Centre of Advanced Technologies and Materials, Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, Olomouc 783 71, Czech Republic.

Publikováno v: The journal of physical chemistry. B [J Phys Chem B] 2021 Jul 22; Vol. 125 (28), pp. 7691-7705. Date of Electronic Publication: 2021 Jul 14.

Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis.

Autor: Jutzi D; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK., Campagne S; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland., Schmidt R; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland., Reber S; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK., Mechtersheimer J; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK., Gypas F; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland.; Friedrich Miescher Institute for Biomedical Research, CH-4058, Basel, Switzerland., Schweingruber C; Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden., Colombo M; Celgene Institute of Translational Research (CITRE), 41092, Seville, Spain., von Schroetter C; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland., Loughlin FE; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland.; Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC, 3800, Australia., Devoy A; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK., Hedlund E; Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden., Zavolan M; Computational and Systems Biology, Biozentrum, University of Basel, CH-4056, Basel, Switzerland., Allain FH; Institute of Molecular Biology and Biophysics, Department of Biology, ETH Zürich, CH-8093, Zürich, Switzerland. allain@bc.biol.ethz.ch., Ruepp MD; United Kingdom Dementia Research Institute Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, Maurice Wohl Clinical Neuroscience Institute, London, UK. marc-david.ruepp@kcl.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2020 Dec 11; Vol. 11 (1), pp. 6341. Date of Electronic Publication: 2020 Dec 11.

Unfolding Mechanism and Fibril Formation Propensity of Human Prion Protein in the Presence of Molecular Crowding Agents.

Autor: Madheswaran, Manoj¹ (AUTHOR), Ventserova, Nataliia¹ (AUTHOR), D'Abrosca, Gianluca² (AUTHOR), Salzano, Giulia³ (AUTHOR), Celauro, Luigi³ (AUTHOR), Cazzaniga, Federico Angelo⁴ (AUTHOR), Isernia, Carla¹ (AUTHOR), Malgieri, Gaetano¹ (AUTHOR), Moda, Fabio⁵ (AUTHOR), Russo, Luigi¹ (AUTHOR), Legname, Giuseppe³ (AUTHOR), Fattorusso, Roberto¹ (AUTHOR) roberto.fattorusso@unicampania.it

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9916. 15p.

The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.

Autor: Loughlin FE; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland; Monash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, 3800 VIC, Australia. Electronic address: fionna.loughlin@monash.edu., Lukavsky PJ; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland., Kazeeva T; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland., Reber S; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland., Hock EM; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland., Colombo M; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3012 Bern, Switzerland., Von Schroetter C; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland., Pauli P; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland., Cléry A; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland., Mühlemann O; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland., Polymenidou M; Institute of Molecular Life Sciences, University of Zurich, 8057 Zurich, Switzerland., Ruepp MD; Department of Chemistry and Biochemistry, University of Bern, 3012 Bern, Switzerland., Allain FH; Department of Biology, Institute of Molecular Biology and Biophysics, ETH Zürich, 8093 Zürich, Switzerland. Electronic address: allain@mol.biol.ethz.ch.

Publikováno v: Molecular cell [Mol Cell] 2019 Feb 07; Vol. 73 (3), pp. 490-504.e6. Date of Electronic Publication: 2018 Dec 20.