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EU-OPENSCREEN:a novel collaborative approach to facilitate chemical biology

Autor: Brennecke, P. (Philip), Rasina, D. (Dace), Aubi, O. (Oscar), Herzog, K. (Katja), Landskron, J. (Johannes), Cautain, B. (Bastien), Vicente, F. (Francisca), Quintana, J. (Jordi), Mestres, J. (Jordi), Stechmann, B. (Bahne), Ellinger, B. (Bernhard), Brea, J. (Jose), Kolanowski, J. (Jacek), Pilarski, R. (Radoslaw), Orzaez, M. (Mar), Pineda-Lucena, A. (Antonio), Laraia, L. (Luca), Nami, F. (Faranak), Zielenkiewicz, P. (Piotr), Paruch, K. (Kamil), Hansen, E. (Espen), von Kries, J. (Jens), Neuenschwander, M. (Martin), Specker, E. (Edgar), Bartunek, P. (Petr), Simova, S. (Sarka), Leśnikowski, Z. (Zbigniew), Krauss, S. (Stefan), Lehtiö, L. (Lari), Bilitewski, U. (Ursula), Brönstrup, M. (Mark), Taskén, K. (Kjetil), Jirgenson, A. (Aigars), Lickert, H. (Heiko), Clausen, M. (Mads), Andersen, J. (Jeanette), Vicent, M. (Maria), Genilloud, O. (Olga), Martinez, A. (Aurora), Nazaré, M. (Marc), Fecke, W. (Wolfgang), Gribbon, P. (Philip)

Compound screening in biological assays and subsequent optimization of hits is indispensable for the development of new molecular research tools and drug candidates. To facilitate such discoveries, the European Research Infrastructure EU-OPENSCREEN w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2423::62a78774070eaa0621f64cf8df17ef87
http://urn.fi/urn:nbn:fi-fe2019081424174

An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells

Autor: Schrade, K, Tröger, J, Eldahshan, A, Zühlke, K, Abdul Azeez, K, Elkins, J, Neuenschwander, M, Oder, A, Elkewedi, M, Jaksch, S, Andrae, K, Li, J, Fernandes, J, Müller, P, Grunwald, S, Marino, S, Vukićević, T, Eichhorst, J, Wiesner, B, Weber, M, Kapiloff, M, Rocks, O, Daumke, O, Wieland, T, Knapp, S, von Kries, J, Klussmann, E

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0191423 (2018)
PLOS ONE, 13(1):e0191423

Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and the enrichment of the water channel aquaporin-2 (AQP2) in the plasma membrane. The membrane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d0b51bd538a205cca48b5e9718fe2d27
http://europepmc.org/articles/PMC5786306

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Microtubule affinity regulating kinase activity in living neurons was examined by a genetically encoded fluorescence resonance energy transfer/fluorescence lifetime imaging-based biosensor: inhibitors with therapeutic potential

Autor: Timm, T., von Kries, J., Li, X., Zempel, H., Mandelkow, E.

Publikováno v: The journal of biological chemistry, 286(48): 41711–41722
The journal of biological chemistry 286(48), 41711-41722 (2011). doi:10.1074/jbc.M111.257865
Journal of Biological Chemistry

BACKGROUND: Deregulation of the protein kinase MARK has been linked to Alzheimer disease. - RESULTS: Mark-specific inhibitors and a biosensor are identified. - CONCLUSION: The inhibitors and the biosensor are tools to provide new insights into the ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::81090cd9da31aad357a3ef6cd9421d44
https://repository.publisso.de/resource/frl:6406519