Exploring Cancer Drugs In Vitro and In Vivo : With Special Reference to Chemosensitivity Testing and Early Clinical Development

Autor: von Heideman, Anne

The aims of this thesis were to investigate the utility of in vitro drug sensitivity testing to optimize the use of cancer chemotherapy and to assess the properties of a new cancer drug in a phase I clinical trial. Tumour cells from patients were ana

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151826

Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma

Autor: Hanna Dahlstrand, Johan Botling, Kjell Öberg, Håkan Ahlström, Bengt Tholander, Gustav J. Ullenhag, Anthoula Koliadi, Anne von Heideman

Publikováno v: Upsala Journal of Medical Sciences
article-version (VoR) Version of Record
Upsala Journal of Medical Sciences, Vol 125, Iss 4, Pp 325-329 (2020)

More effective treatments are needed for low-grade serous ovarian carcinoma (LGSOC). Our patient, who suffers from metastatic LGSOC, had received all established treatments. Sequencing analysis revealed an activating BRAF mutation. Therefore, combine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d547b704c1972bd3f703a77521f0e2
https://pubmed.ncbi.nlm.nih.gov/33043759

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome.

Autor: von Heideman, Anne¹, Tholander, Bengt¹, Grundmark, Birgitta², Cajander, Stefan³, Gerdin, Eva⁴, Holm, Leif⁵, Axelsson, Agneta⁶, Rosenberg, Per⁷, Mahteme, Haile², Daniel, Erika¹, Larsson, Rolf⁸, Nygren, Peter¹

Publikováno v: Acta Oncologica. Feb2014, Vol. 53 Issue 2, p242-250. 9p.

A Novel B-cell Line (U-2932) Established from a Patient with Diffuse Large B-cell Lymphoma Following Hodgkin Lymphoma

Autor: Ulf Thunberg, Richard Rosenquist, Mattias Berglund, Bengt Glimelius, Rose-Marie Amini, Anne von Heideman, Gunilla Enblad, Svetlana Lagercrantz, Christer Sundström, Jonas Bergh

Publikováno v: Leukemia & Lymphoma. 43:2179-2189

Little is known about mechanisms leading to secondary non-Hodgkin lymphomas (NHL) in patients treated for Hodgkin lymphoma (HL). Our aim was to characterise in detail a cell line derived from a diffuse large B-cell lymphoma (DLBCL) that had developed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb20fe1767c9c7de645fad6bff0bb424
https://doi.org/10.1080/1042819021000032917

Chemotherapeutic drug sensitivity of primary cultures of epithelial ovarian cancer cells from patients in relation to tumour characteristics and therapeutic outcome

Autor: Birgitta Grundmark, Peter Nygren, Rolf Larsson, Eva Gerdin, Bengt Tholander, Anne von Heideman, Leif Holm, Agneta Axelsson, Stefan Cajander, Per Rosenberg, Haile Mahteme, Erika Daniel

Publikováno v: Acta oncologica (Stockholm, Sweden). 53(2)

Background. A number of chemotherapeutic drugs are active in epithelial ovarian cancer (EOC) but so far choice of drugs for treatment is mostly empirically based. Testing of drug activity in tumour cells from patients might provide a rationale for a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119dadd5ff86486d73de88205966c070
https://pubmed.ncbi.nlm.nih.gov/23713890