Case report: Tenosynovial giant cell tumor.

Autor: Fähnrich A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital of Schleswig- Holstein, Lübeck, Germany., Gasimova Z; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Maluje Y; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., Ott F; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany., Sievert H; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Fliedner S; University Cancer Center Schleswig-Holstein, University Hospital of Schleswig- Holstein, Lübeck, Germany., Reimer N; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital of Schleswig- Holstein, Lübeck, Germany., Künstner A; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital of Schleswig- Holstein, Lübeck, Germany., Gebauer N; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Kebenko M; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Kirfel J; Institut for Pathology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Sailer VW; Institut for Pathology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Röcken C; Department of Pathology, Christian-Albrechts-University, Kiel, Germany., Konukiewitz B; Department of Pathology, Christian-Albrechts-University, Kiel, Germany., Klapper W; Institut for Haematopathology, Christian-Albrechts-University, Kiel, Germany., Frydrychowicz A; Department of Radiology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Mogadas S; Department of Radiology, University Hospital of Schleswig-Holstein, Lübeck, Germany., Huebner G; Department of Internal Medicine III, Ameos Krankenhausgesellschaft Ostholstein, Eutin, Germany., Busch H; Medical Systems Biology Group, Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.; University Cancer Center Schleswig-Holstein, University Hospital of Schleswig- Holstein, Lübeck, Germany., Khandanpour C; Department of Hematology and Oncology, University Hospital of Schleswig-Holstein, Lübeck, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Sep 26; Vol. 14, pp. 1445427. Date of Electronic Publication: 2024 Sep 26 (Print Publication: 2024).

Comprehensive genetic profiling and molecularly guided treatment for patients with primary CNS tumors.

Autor: Kuehn JC; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Metzger P; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Neidert N; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany., Matysiak U; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Gräßel L; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Philipp U; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bleul S; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Pauli T; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Falkenstein J; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Bertemes H; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Cysar S; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Hess ME; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Faculty of Biology, University of Freiburg, Freiburg, Germany., Frey AV; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Duque-Afonso J; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Schorb E; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Machein M; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany., Beck J; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany., Schnell O; Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Luebeck, Germany., Illert AL; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Department of Medicine III, Faculty of Medicine, Klinikum Rechts der Isar, Technical University Munich (TUM), Munich, Germany., Peters C; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Brummer T; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Institute of Molecular Medicine and Cell Research, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Prinz M; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.; Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Miething C; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Becker H; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany., Lassmann S; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Werner M; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Institute for Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Börries M; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Institute of Medical Bioinformatics and Systems Medicine, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany., Duyster J; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany., Heiland DH; Department of Neurosurgery, Medical Center-University of Freiburg, Faculty of Medicine Freiburg, University of Freiburg, Freiburg, Germany.; Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander University (FAU) Erlangen-Nürnberg, Erlangen, Germany., Sankowski R; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany.; Institute of Neuropathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Scherer F; Department of Medicine I, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. florian.scherer@uniklinik-freiburg.de.; Comprehensive Cancer Center Freiburg, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. florian.scherer@uniklinik-freiburg.de.; German Cancer Consortium (DKTK Partner site Freiburg, a partnership between DKFZ and Medical Center-University of Freiburg, Heidelberg, Germany. florian.scherer@uniklinik-freiburg.de.

Publikováno v: NPJ precision oncology [NPJ Precis Oncol] 2024 Aug 14; Vol. 8 (1), pp. 180. Date of Electronic Publication: 2024 Aug 14.

FRACTION: protocol of a phase II study of Fedratinib and Nivolumab combination in patients with myelofibrosis and resistance or suboptimal response to JAK-inhibitor treatment of the German MPN study group (GSG-MPN).

Autor: Isfort S; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany., von Bubnoff N; Department of Hematology and Oncology, University Hospital Lübeck, Lübeck, Germany., Al-Ali HK; University Hospital Halle (Saale), Krukenberg Cancer Center Halle, Halle, Germany., Becker H; Department of Medicine I - Medical Center - University of Freiburg, Faculty of Medicine, University of , Freiburg, Freiburg, Germany., Götze T; Krankenhaus Nordwest, University Cancer Center (UCT), Frankfurt, Germany.; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., le Coutre P; Department of Hematology, Oncology and Stem Cell Transplantation, Charite Berlin, Germany., Griesshammer M; Mühlenkreisklinikum Minden, Universitätsklinikum Bochum, Minden, Germany., Moskwa C; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany., Wohn L; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Riedel J; Institut für Klinische Krebsforschung IKF Am Krankenhaus Nordwest, Frankfurt, Germany., Palandri F; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia 'Seràgnoli', Bologna, Italy., Manz K; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany.; Institute for Community Medicine - SHIP-KEF, Universitätsmedizin Greifswald, Greifswald, Germany., Hochhaus A; Klinik für Innere Medizin II, Abteilung Hämatologie und Internistische Onkologie, Universitätsklinikum Jena, Jena, Germany., Döhner K; Department of Internal Medicine III, University Hospital of Ulm, Ulm, Germany., Heidel FH; Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School (MHH), Carl-Neuberg-Str. 1, Hannover, 30625, Germany. heidel.florian@mh-hannover.de.; Internal Medicine C, Hematology, Oncology, Stem Cell Transplantation and Palliative Care, University Medicine Greifswald, Greifswald, Germany. heidel.florian@mh-hannover.de.

Publikováno v: Annals of hematology [Ann Hematol] 2024 Aug; Vol. 103 (8), pp. 2775-2785. Date of Electronic Publication: 2024 Jul 05.

Type II mode of JAK2 inhibition and destabilization are potential therapeutic approaches against the ruxolitinib resistance driven myeloproliferative neoplasms.

Autor: Gorantla SP; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany.; Department of Internal Medicine I, University Medical Center Freiburg, Freiburg, Germany., Prince G; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany., Osius J; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany., Dinesh DC; Department of Biochemistry and Molecular Biology, Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czechia., Boddu V; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany., Duyster J; Department of Internal Medicine I, University Medical Center Freiburg, Freiburg, Germany., von Bubnoff N; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Lübeck, Germany.

Publikováno v: Frontiers in oncology [Front Oncol] 2024 Jul 18; Vol. 14, pp. 1430833. Date of Electronic Publication: 2024 Jul 18 (Print Publication: 2024).

Serum chemistry profiling and prognostication in systemic mastocytosis: a registry-based study of the ECNM and GREM.

Autor: Lübke J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Schmid A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Christen D; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Oude Elberink HNG; Department of Allergology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Span LFR; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Niedoszytko M; Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland., Gorska A; Department of Allergology, Medical University of Gdańsk, Gdańsk, Poland., Lange M; Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, Gdańsk, Poland., Gleixner KV; Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Hadzijusufovic E; Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria.; Department/University Clinic for Companion Animals and Horses, Internal Medicine Small Animals, University Clinic for Small Animals, University of Veterinary Medicine, Vienna, Austria., Stefan A; University Clinic for Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Angelova-Fischer I; Department of Dermatology and Venereology, Allergy Center, Kepler University Hospital, Johannes Kepler University, Linz, Austria., Zanotti R; Department of Medicine, Section of Hematology, Verona University Hospital, Verona, Italy., Bonifacio M; Department of Medicine, Section of Hematology, Verona University Hospital, Verona, Italy., Bonadonna P; Allergy Unit, Verona University Hospital, Verona, Italy., Shoumariyeh K; Department of Medicine I, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany., von Bubnoff N; Department of Medicine I, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.; German Cancer Consortium (DKTK), partner site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany.; Department of Hematology and Oncology, Medical Center, University of Schleswig-Holstein, Campus Lübeck, Lübeck, Germany., Müller S; Department of Dermatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Perkins C; Stanford Cancer Institute, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA., Elena C; Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Malcovati L; Hematology Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Hagglund H; Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Mattsson M; Division of Hematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Parente R; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Varkonyi J; Department of Hematology, Semmelweis University, Budapest, Hungary., Fortina AB; Department of Medicine, Pediatric Dermatology Unit, University of Padova, Padova, Italy., Caroppo F; Department of Medicine, Pediatric Dermatology Unit, University of Padova, Padova, Italy., Brockow K; Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany., Zink A; Department of Dermatology and Allergy, School of Medicine, Technical University of Munich, Munich, Germany., Breynaert C; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium., Leven T; KU Leuven Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group and MASTeL, University Hospitals Leuven, Leuven, Belgium., Yavuz AS; Division of Hematology, Istanbul Medical School, University of Istanbul, Istanbul, Turkey., Doubek M; Department of Internal Medicine - Hematology and Oncology, University Hospital Brno & Faculty of Medicine, Masaryk University, Brno, Czech Republic., Sabato V; Department of Immunology-Allergology-Rheumatology, Faculty of Medicine and Health Sciences, University of Antwerp and Antwerp University Hospital, Antwerpen, Belgium., Schug T; Department of Dermatology and Venereology, University Hospital Graz, Graz, Austria., Hartmann K; Division of Allergy, Department of Dermatology, University Hospital Basel and University of Basel, Basel, Switzerland.; Department of Biomedicine, University Hospital Basel and University of Basel, Basel, Switzerland., Triggiani M; Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy., Gotlib J; Stanford Cancer Institute, Stanford University School of Medicine/Stanford Cancer Institute, Stanford, CA., Hermine O; French Reference Center for Mastocytosis, Hospital Necker, Assistance Publique Hôpitaux de Paris, Imagine Institute, University Paris Descartes, Paris, France., Arock M; French Reference Center for Mastocytosis, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris, University Paris Sorbonne, Paris, France., Kluin-Nelemans HC; Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Panse J; Department of Oncology, Hematology, Hemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany.; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf, Aachen, Germany., Sperr WR; Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Valent P; Division of Hematology & Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria.; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Reiter A; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany., Schwaab J; Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.

Publikováno v: Blood advances [Blood Adv] 2024 Jun 11; Vol. 8 (11), pp. 2890-2900.