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The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities

Autor: Sayuri Mototani, Fumihiro Kawagoe, Kaori Yasuda, Hiroki Mano, Toshiyuki Sakaki, Atsushi Kittaka

Publikováno v: Molecules, Vol 27, Iss 16, p 5352 (2022)

In this paper, we report an efficient synthetic route for the 23,23-difluoro-25-hydroxyvitamin D3 (5) and its 24-hydroxylated analogues (7,8), which are candidates for the CYP24A1 main metabolites of 5. The key fragments, 23,23-difluoro-CD-ring precu

Externí odkaz: https://doaj.org/article/3fe0d8b40b954d64881c01047bf1b804

Evaluation of Vitamin D3 metabolite (25-OH Vit D3), Neurotransmitter (ACh), and the Expression of Proinflammatory Cytokines (IL-6 and TNF-α) in Tissue Homogenate after Administration of Biofield Energy Healing-based Novel Proprietary Test Formulation and Biofield Treatment per se to the Animals in Vitamin D3 Deficiency Diet (VDD)-induced Sprague Dawley Rats

Autor: Alice Branton, Snehasis Jana, Dahryn Trivedi, Mahendra Kumar Trivedi

Publikováno v: Journal of Neurological Research and Therapy. 3:1-11

A novel proprietary test formulation was designed which included minerals, vitamins, β-carotene, cannabidiol isolate,and Panax ginseng extract. This present study was evaluated the impact of the Trivedi Effect® on novel proprietary test formulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58b27cb03d5ca9c0a6fa5bc140808ad2
https://doi.org/10.14302/issn.2470-5020.jnrt-21-3755

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Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism

Autor: Atsushi Kittaka, Toshiyuki Sakaki, Kaori Yasuda, Fumihiro Kawagoe, Sayuri Mototani, Hiroki Mano

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, Vol 22, Iss 11863, p 11863 (2021)

Two 24-fluoro-25-hydroxyvitamin D3 analogues (3,4) were synthesized in a convergent manner. The introduction of a stereocenter to the vitamin D3 side-chain C24 position was achieved via Sharpless dihydroxylation, and a deoxyfluorination reaction was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306cef0bee8ece908749ddc3db410522
https://doi.org/10.3390/ijms222111863