Zobrazeno 1 - 10
of 578
pro vyhledávání: '"vision restoration"'
Publikováno v:
Clinical Ophthalmology, Vol Volume 18, Pp 2785-2795 (2024)
Javier Mendicute,1,2 Gorka Lauzirika,1,3 Igor Illarramendi,1 Itziar Martínez-Soroa1,2 1Miranza Begitek, Donostia - San Sebastián, 20012, Spain; 2Donostia University Hospital, Donostia - San Sebastián, 20014, Spain; 3R&D Department of Miranza Group
Externí odkaz:
https://doaj.org/article/3eae32691c8440929f2df5ac1d2b1dd2
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Vision restoration is one of the most promising applications of optogenetics. However, it is limited due to the poor-sensitivity, slow-kinetics and narrow band absorption spectra of opsins. Here, a detailed theoretical study of retinal gangl
Externí odkaz:
https://doaj.org/article/8f748d89ccbd44a29e318c5e5ae21b9e
Autor:
Boyuan Yan, Suresh Viswanathan, Scott E. Brodie, Wen-Tao Deng, Kirsten E. Coleman, William W. Hauswirth, Sheila Nirenberg
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 406-417 (2023)
Optogenetic gene therapies offer a promising strategy for restoring vision to patients with retinal degenerative diseases, such as retinitis pigmentosa (RP). Several clinical trials have begun in this area using different vectors and optogenetic prot
Externí odkaz:
https://doaj.org/article/7c6b4f3a22b54425a4e36725bb472ee2
Autor:
Arathy Kartha, Roksana Sadeghi, Chris Bradley, Brittnee Livingston, Chau Tran, Will Gee, Gislin Dagnelie
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionUltra low vision (ULV) refers to profound visual impairment where an individual cannot read even the top line of letters on an ETDRS chart from a distance of 0.5 m. There are limited tools available to assess visual ability in ULV. The ai
Externí odkaz:
https://doaj.org/article/2a46daa15cc74e1c8b37fbc733e600e4
Autor:
Thomas V. Johnson, MD, PhD, Petr Baranov, MD, PhD, Adriana Di Polo, PhD, Brad Fortune, OD, PhD, Kimberly K. Gokoffski, MD, PhD, Jeffrey L. Goldberg, MD, PhD, William Guido, PhD, Alex L. Kolodkin, PhD, Carol A. Mason, PhD, Yvonne Ou, MD, Thomas A. Reh, PhD, Ahmara G. Ross, MD, PhD, Brian C. Samuels, MD, PhD, Donald J. Zack, MD, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 4, Pp 100390- (2023)
Purpose: The Retinal Ganglion Cell (RGC) Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) consortium was founded in 2021 to help address the numerous scientific and clinical obstacles that impede development of vision-
Externí odkaz:
https://doaj.org/article/97c541baf29f4361882762299e8ef428
Autor:
Hanen Khabou, Elaine Orendorff, Francesco Trapani, Marco Rucli, Melissa Desrosiers, Pierre Yger, Deniz Dalkara, Olivier Marre
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 31, Iss , Pp 101107- (2023)
Most inherited retinal dystrophies display progressive photoreceptor cell degeneration leading to severe visual impairment. Optogenetic reactivation of inner retinal neurons is a promising avenue to restore vision in retinas having lost their photore
Externí odkaz:
https://doaj.org/article/b78a68eae9bd436db9cd81cc7fa020a7
Autor:
Kashish Parnami, Anwesha Bhattacharyya
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
Inherited progressive degeneration of photoreceptors such as retinitis pigmentosa (RP) is the most common cause of blindness leading to severe vision impairment affecting ~1 in 5,000 people worldwide. Although the function and morphology of the photo
Externí odkaz:
https://doaj.org/article/9b90b8f76407467b9eae9eb5f073a6ce
Akademický článek
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Autor:
A. Maddalena, S. Kleinlogel
Publikováno v:
Frontiers in Drug Delivery, Vol 3 (2023)
Retinitis pigmentosa, an inherited form of retinal degeneration, is characterized by a progressive loss of rods and subsequent degeneration of cones, leading to blindness. However, the remaining neural portion of the retina (bipolar and ganglion cell
Externí odkaz:
https://doaj.org/article/14971a8d7bd5477c920fcfafb888fd7a
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 14207 (2023)
Loss of photoreceptors in retinal degenerative diseases also impacts the inner retina: bipolar cell dendrites retract, neurons rewire, and protein expression changes. ON-bipolar cells (OBCs) represent an attractive target for optogenetic vision resto
Externí odkaz:
https://doaj.org/article/ce655fc305ea40deadfb8e3deeaa30a8