More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells

Autor: Gordon Dougan, Ana Elena Pérez-Cobas, Christophe Rusniok, Sandra Reuter, Carmen Buchrieser, Jasmin Demirtas, Shivani Pasricha, Elizabeth L. Hartland, Gunnar N. Schroeder, Gad Frankel, S. Jarraud, Sonia Mondino, Laura Gomez-Valero, Johannes Crumbach, Monica Rolando, Stéphane Descorps-Declère, Danielle Carson

Publikováno v: Gomez-Valero, L, Rusniok, C, Carson, D, Mondino, S, Pérez-Cobas, A E, Rolando, M, Pasricha, S, Reuter, S, Demirtas, J, Crumbach, J, Descorps-Declere, S, Hartland, E L, Jarraud, S, Dougan, G, Schroeder, G N, Frankel, G & Buchrieser, C 2019, ' More than 18,000 effectors in the Legionella genus genome provide multiple, independent combinations for replication in human cells ', Proceedings of the National Academy of Sciences of the United States of America . https://doi.org/10.1073/pnas.1808016116, https://doi.org/10.1101/350777
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (6), pp.2265-2273. ⟨10.1073/pnas.1808016116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (6), pp.2265-2273. ⟨10.1073/pnas.1808016116⟩

The genus Legionella comprises 65 species, among which Legionella pneumophila is a human pathogen causing severe pneumonia. To understand the evolution of an environmental to an accidental human pathogen, we have functionally analyzed 80 Legionella g

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