Zobrazeno 1 - 10
of 116
pro vyhledávání: '"virtual docking"'
Autor:
Yves L. Janin
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1355-1378 (2022)
This perspective is an attempt to document the problems that medicinal chemists are facing in drug discovery. It is also trying to identify relevant/possible, research areas in which academics can have an impact and should thus be the subject of gran
Externí odkaz:
https://doaj.org/article/a1033dcbdd2443598749efea074ba5dc
Autor:
Suchitra Maheswari Ajjarapu, Apoorv Tiwari, Gohar Taj, Dev Bukhsh Singh, Sakshi Singh, Sundip Kumar
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract Background Ovarian cancer is the world’s dreaded disease and its prevalence is expanding globally. The study of integrated molecular networks is crucial for the basic mechanism of cancer cells and their progression. During the present inve
Externí odkaz:
https://doaj.org/article/ab676c28deb344d19d67adb2976dc443
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Considering the significant impact of the recent COVID-19 outbreak, development of broad-spectrum antivirals is a high priority goal to prevent future global pandemics. Antiviral development processes generally emphasize targeting a specific protein
Externí odkaz:
https://doaj.org/article/2650cc70537c4b1e9b4585923e0623e4
Publikováno v:
Molecules, Vol 28, Iss 8, p 3317 (2023)
Bestrophin 1 (Best1) is a chloride channel that localises to the plasma membrane of retinal pigment epithelium (RPE) cells. Mutations in the BEST1 gene are associated with a group of untreatable inherited retinal dystrophies (IRDs) called bestrophino
Externí odkaz:
https://doaj.org/article/2e884a38174043fbbad87c044cc5fddf
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics and the high costs for clinical trials, hampers the development of novel antimicrobial agents with improved efficacy and safety. Subsequently, in sili
Externí odkaz:
https://doaj.org/article/9724d5a05dcb469a8d2e9bd77c097e10
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Virtual screening is a cost- and time-effective alternative to traditional high-throughput screening in the drug discovery process. Both virtual screening approaches, structure-based molecular docking and ligand-based cheminformatics, suffer from com
Externí odkaz:
https://doaj.org/article/d177251ecc01442b9db8220579d233de
Publikováno v:
Drug Design, Development and Therapy, Vol Volume 14, Pp 1779-1798 (2020)
Ying-Qi Feng,1,* Shuang-Xi Gu,1,* Yong-Shou Chen,1,* Xu-Dong Gao,2 Yi-Xin Ren,1 Jian-Chao Chen,3 Yin-Ying Lu,2 Heng Zhang,1 Shuang Cao1,4 1Key Laboratory for Green Chemical Process of Ministry of Education, School of Chemical Engineering and Pharmacy
Externí odkaz:
https://doaj.org/article/2d933dcd7364498c86e4f41a44f32ee7
Autor:
Michele Fiore, Michele Mosconi, Francesco Bonì, Alice Parodi, Annalisa Salis, Bruno Tasso, Eloise Mastrangelo, Enrico Millo, Federica Cossu
Publikováno v:
Molecules, Vol 28, Iss 1, p 446 (2023)
Inhibitor of Apoptosis Proteins (IAPs) are validated targets for cancer therapy, and the deregulation of their activities within the NF-κB pathway correlates with chemoresistance events, even after treatment with IAPs-antagonists in the clinic (Smac
Externí odkaz:
https://doaj.org/article/29fc0bce5e904e8f953a500626187fa6
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Akademický článek
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