Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock

Autor: Edwige Col, Neda Hoghoughi, Solenne Dufour, Jessica Penin, Sivan Koskas, Virginie Faure, Maria Ouzounova, Hector Hernandez-Vargash, Nicolas Reynoird, Sylvain Daujat, Eric Folco, Marc Vigneron, Robert Schneider, André Verdel, Saadi Khochbin, Zdenko Herceg, Cécile Caron, Claire Vourc’h

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract The heat shock response is characterized by the transcriptional activation of both hsp genes and noncoding and repeated satellite III DNA sequences located at pericentric heterochromatin. Both events are under the control of Heat Shock Facto

Externí odkaz: https://doaj.org/article/bca9308205324eb9836b10ca9adb63ee

Chromosome Y pericentric heterochromatin is a primary target of HSF1 in male cells

Autor: André Verdel, Edwige Col, Claire Vourc'h, Sabrina Fritah, Virginie Faure, Jessica Penin, Daphné Seigneurin-Berny, Solenne Dufour

Publikováno v: Chromosoma
Chromosoma, 2021, 130 (1), pp.53-60. ⟨10.1007/s00412-021-00751-2⟩
Chromosoma, Springer Verlag, 2021, 130 (1), pp.53-60. ⟨10.1007/s00412-021-00751-2⟩

The heat shock factor 1 (HSF1)-dependent transcriptional activation of human pericentric heterochromatin in heat-shocked cells is the most striking example of transcriptional activation of heterochromatin. Until now, pericentric heterochromatin of ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b8e5563f177c46281420e54a586f02
https://doi.org/10.1007/s00412-021-00751-2

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

Autor: Lydia Pernet, Saadi Khochbin, Benoit Gilquin, Claire Vourc’h, Virginie Faure, Solenne Dufour-Guérin

Publikováno v: Molecular Biology of the Cell

A full response to heat shock depends on the duration of HSF1 activation, which is controlled by the deacetylase HDAC6, known to bind ubiquitin residues, and by AAA ATPase p97/VCP. This new regulatory process relies on the extent of protein ubiquitin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9cd56c4b0922c5ad75d979a94817620
http://europepmc.org/articles/PMC4263459

Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line

Autor: Thomas Wenner, Virginie Faure, Christine J. Farr, Emer Bourke, Ciaran G. Morrison, Shunichi Takeda, Carol Cooley

Publikováno v: DNA Repair. 7:713-724

Telomere repeat sequences are added to linear chromosome ends by telomerase, an enzyme comprising a reverse transcriptase (TERT) and an RNA template component (TR). We aimed to investigate TR in the DT40 B-cell tumour line using gene targeting, but w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06cc06cf03166caebd18c2d2f09763a
https://doi.org/10.1016/j.dnarep.2008.01.008

Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells

Autor: Jillian L. Stewart, Virginie Faure, Christine J. Farr, Sonie Modino, Katie M. Baird, Carol Cooley, Thomas Wenner, Ciaran G. Morrison, Predrag Slijepcevic

Publikováno v: Molecular biology of the cell. 20(10)

© 2009 by The American Society for Cell Biology. The telomere end-protection complex prevents the ends of linear eukaryotic chromosomes from degradation or inappropriate DNA repair. The homodimeric double-stranded DNA-binding protein, Trf1, is a com

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93826200f7b2aa9a0b0ffae475a0f45
https://pubmed.ncbi.nlm.nih.gov/19321665