The importance of transmembrane domain interactions in the viral control of apoptosis

Autor: Gerard Duart, Ismael Mingarro, Luis Martinez-Gil

Publikováno v: Molecular & Cellular Oncology, Vol 8, Iss 3 (2021)

Viral control of apoptosis occurs through the expression of viral encoded anti-apoptotic B-cell lymphoma 2 (BCL2) analogs. These proteins are thought to restrain apoptosis by interacting with cellular BCL2 family members. We identified that protein-p

Externí odkaz: https://doaj.org/article/ee38483f627c4e60a415cb617edcb7ed

A179l, a new viral Bcl2 homolog targeting beclin 1 autophagy related protein

Autor: Inmaculada Galindo, M. Cabezas, Bruno Hernáez, Raquel Muñoz-Moreno, Miguel Ángel Cuesta-Geijo, Covadonga Alonso

Publikováno v: ResearcherID
Repositorio de Resultados de Investigación del INIA
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA
Scopus-Elsevier
INIA: Repositorio de Resultados de Investigación del INIA

Autophagy is a relevant cellular defense mechanism that directly eliminates intracellular pathogens and has a crucial role for innate and adaptive immune responses. Some viruses have developed tools to counteract this cellular response. A179L, the vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc76ca9e5d87b80422849028d3378d7
http://hdl.handle.net/20.500.12792/2067