Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican

Autor: Thomas Muley, Stefan Günther, Hauke Winter, Werner Seeger, Mark Kriegsmann, Kati Turkowski, Friedrich Grimminger, Reinhard Dammann, Soni Savai Pullamsetti, Andreas Weigert, Andreas Guenther, Rajkumar Savai, David Brunn, Georgios T. Stathopoulos, Michael Thomas

Publikováno v: Cancers
Cancers, Vol 13, Iss 208, p 208 (2021)
Volume 13
Issue 2
Cancers 13:208 (2021)

Transcription factors can serve as links between tumor microenvironment signaling and oncogenesis. Interferon regulatory factor 9 (IRF9) is recruited and expressed upon interferon stimulation and is dependent on cofactors that exert in tumor-suppress

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http://europepmc.org/articles/PMC7827113

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Loss of versican and production of hyaluronan in lung epithelial cells are associated with airway inflammation during RSV infection.

Autor: Kellar GG; Department of Defense, United States Army, Washington, USA; Benaroya Research Institute, Seattle, Washington, USA; Department of Immunology, University of Washington, Seattle, Washington, USA., Barrow KA; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA., Rich LM; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA., Debley JS; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA; Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA., Wight TN; Benaroya Research Institute, Seattle, Washington, USA., Ziegler SF; Benaroya Research Institute, Seattle, Washington, USA; Department of Immunology, University of Washington, Seattle, Washington, USA., Reeves SR; Center for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, Washington, USA; Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA. Electronic address: stephen.reeves@seattlechildrens.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2021 Jan-Jun; Vol. 296, pp. 100076. Date of Electronic Publication: 2020 Nov 21.

Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation.

Autor: Kang I; From the Matrix Biology Program and., Harten IA; From the Matrix Biology Program and., Chang MY; the Department of Comparative Medicine and Center for Lung Biology, University of Washington, Seattle, Washington 98109, and., Braun KR; From the Matrix Biology Program and., Sheih A; Immunology Program, Benaroya Research Institute, Seattle, Washington 98101., Nivison MP; From the Matrix Biology Program and., Johnson PY; From the Matrix Biology Program and., Workman G; From the Matrix Biology Program and., Kaber G; From the Matrix Biology Program and., Evanko SP; From the Matrix Biology Program and., Chan CK; From the Matrix Biology Program and., Merrilees MJ; the Department of Anatomy and Medical Imaging, School of Medical Sciences, University of Auckland, Auckland 1010, New Zealand., Ziegler SF; Immunology Program, Benaroya Research Institute, Seattle, Washington 98101., Kinsella MG; From the Matrix Biology Program and., Frevert CW; the Department of Comparative Medicine and Center for Lung Biology, University of Washington, Seattle, Washington 98109, and., Wight TN; From the Matrix Biology Program and twight@benaroyaresearch.org.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2017 Jan 06; Vol. 292 (1), pp. 51-63. Date of Electronic Publication: 2016 Nov 28.