Zobrazeno 1 - 10
of 761
pro vyhledávání: '"ventricular myocyte"'
Autor:
Alessandro Trancuccio, Carmen Tarifa, Rossana Bongianino, Silvia G. Priori, Demetrio J. Santiago
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Timothy syndrome type 1 (TS1), a malignant variant of Long QT Syndrome, is caused by L-type Ca2+ Channel (LTCC) inactivation defects secondary to the p.Gly406Arg mutation in the CACNA1C gene. Leveraging on the experimental in vitro data from
Externí odkaz:
https://doaj.org/article/a355fcb3ee40426d936444aaa1153e00
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1371 (2024)
Previous studies have observed alterations in excitation–contraction (EC) coupling during end-stage heart failure that include action potential and calcium (Ca2+) transient prolongation and a reduction of the Ca2+ transient amplitude. Underlying th
Externí odkaz:
https://doaj.org/article/06a1d2fc0b2b40e39addabbf52512765
Akademický článek
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Akademický článek
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Publikováno v:
Biomolecules, Vol 13, Iss 8, p 1259 (2023)
Calcium (Ca2+) sparks are the elementary events of excitation–contraction coupling, yet they are not explicitly represented in human ventricular myocyte models. A stochastic ventricular cardiomyocyte human model that adapts to intracellular Ca2+ ([
Externí odkaz:
https://doaj.org/article/ab0704475f0241f6996558e6c961f2bf
Autor:
Chunyun Du, Randall L. Rasmusson, Glenna C. Bett, Brandon Franks, Henggui Zhang, Jules C. Hancox
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
The congenital short QT syndrome (SQTS) is a cardiac condition that leads to abbreviated ventricular repolarization and an increased susceptibility to arrhythmia and sudden death. The SQT3 form of the syndrome is due to mutations to the KCNJ2 gene th
Externí odkaz:
https://doaj.org/article/1e1c14cfffb44df191221540c32398c0
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1577 (2022)
Calcium sparks are the elementary Ca2+ release events in excitation-contraction coupling that underlie the Ca2+ transient. The frequency-dependent contractile force generated by cardiac myocytes depends upon the characteristics of the Ca2+ transients
Externí odkaz:
https://doaj.org/article/aa66bcb404c348818f2a90aa4bc1a0d1
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Muscarinic receptors expressed in cardiac myocytes play a critical role in the regulation of heart function by the parasympathetic nervous system. How the structural organization of cardiac myocytes affects the regulation of Ca2+ handling by muscarin
Externí odkaz:
https://doaj.org/article/b33319554131402197c7e3bf85aacf26